Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.
about
Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearancePerfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factorsThe role of transporters in toxicity and diseaseLigand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genesEnhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPSFarnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory responseEvolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile saltsCombined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.Evolution of pharmacologic specificity in the pregnane X receptor.Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.The PXR is a drug target for chronic inflammatory liver disease.Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s.Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alphaRegulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease.Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CARThe expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells.Xenobiotic export pumps, endothelin signaling, and tubular nephrotoxicants--a case of molecular hijacking.Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells.Cholestatic liver disease: pathophysiology and therapeutic options.Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.Mouse Bsep ATPase assay: a nonradioactive tool for assessment of the cholestatic potential of drugs.Role of MRP4 and MRP5 in biology and chemotherapy.Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.Farnesoid X receptor represses hepatic human APOA gene expression.Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice.Systematic review: ursodeoxycholic acid--adverse effects and drug interactions.ATP binding cassette transporter gene expression in rat liver progenitor cellsRegulation of drug and bile salt transporters in liver and intestine.Regulation of hepatic ABCC transporters by xenobiotics and in disease states.New perspectives for the treatment of cholestasis: lessons from basic science applied clinically.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.The enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts.Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ miceCross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences.
P2860
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P2860
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Disrupted bile acid homeostasi ...... sporters, and cytochrome P450.
@en
type
label
Disrupted bile acid homeostasi ...... sporters, and cytochrome P450.
@en
prefLabel
Disrupted bile acid homeostasi ...... sporters, and cytochrome P450.
@en
P2093
P2860
P356
P1476
Disrupted bile acid homeostasi ...... sporters, and cytochrome P450.
@en
P2093
B J Komoroski
E G Schuetz
F J Gonzalez
J D Schuetz
P2860
P304
39411-39418
P356
10.1074/JBC.M106340200
P407
P577
2001-08-16T00:00:00Z