Use of thermal melt curves to assess the quality of enzyme preparations
about
Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterizationStructures of phosphopantetheine adenylyltransferase from Burkholderia pseudomalleiStructural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitisCrystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparumStructure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNABiochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active CompoundsIdentification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia lambliaPoLi: A Virtual Screening Pipeline Based on Template Pocket and Ligand Similarity.Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.Experimental validation of FINDSITE(comb) virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders.Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors.Ligand induced stabilization of the melting temperature of the HSV-1 single-strand DNA binding protein using the thermal shift assay.Novel small molecule binders of human N-glycanase 1, a key player in the endoplasmic reticulum associated degradation pathway.Meltdown: A Tool to Help in the Interpretation of Thermal Melt Curves Acquired by Differential Scanning Fluorimetry.Analysis of protein stability and ligand interactions by thermal shift assay.Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma.
P2860
Q26996528-3AFF42D5-885D-4C44-97F6-B8EDCAD69057Q27673506-9BD25ADB-DBC6-45F1-8682-0A41CAC52311Q27675011-69846B78-F191-46AA-B513-29893E467FECQ27677731-677DA375-4A80-4AD9-B917-8DBD3FBD1641Q27678475-265173CC-D3AE-4749-8943-5EF6A758E495Q28550478-393F364A-4A3D-438E-B305-AABD4D3BBE46Q28553158-6A9AC67F-F672-41AC-8B8E-10BFC8A17174Q30377334-730675AE-FECE-4923-A0C5-D99F4AF74B23Q33682916-D6BA4CD0-4D97-4B0D-A58D-F2DA4D7D5CA2Q33685192-5AD0AAFB-ED25-4990-9E1B-C2F6D638C3FEQ34463959-DCB6DF02-A64C-4DAA-995B-DCEA25966F04Q34625263-8A4304C9-61B3-4A19-B71F-A7FDA5EE4B3EQ38291144-1C1A9FD9-60EB-442D-9441-3245B0D3F16CQ41007067-D14F7058-5439-436D-B63D-43666C1EB9B2Q43152363-0C490183-8C0A-4911-A636-19FD86976B2BQ50873769-6B9F9E07-D33C-4FEE-9128-967559705438
P2860
Use of thermal melt curves to assess the quality of enzyme preparations
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Use of thermal melt curves to assess the quality of enzyme preparations
@en
type
label
Use of thermal melt curves to assess the quality of enzyme preparations
@en
prefLabel
Use of thermal melt curves to assess the quality of enzyme preparations
@en
P2093
P2860
P356
P1476
Use of thermal melt curves to assess the quality of enzyme preparations
@en
P2093
Alberto J Napuli
Andrew P Thomas
David J Leibly
Janhavi Bhandari
Kuzma V Kovzun
Lisa J Castaneda
Michael H Gelb
Panqing He
Wesley C Van Voorhis
Wim G J Hol
P2860
P304
P356
10.1016/J.AB.2009.12.018
P407
P577
2009-12-14T00:00:00Z