Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk.
about
Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinasesThe Phox homology (PX) domain, a new player in phosphoinositide signallingBCR Signaling Inhibitors: an Overview of Toxicities Associated with Ibrutinib and Idelalisib in Patients with Chronic Lymphocytic LeukemiaSecond-generation inhibitors of Bruton tyrosine kinaseManagement of chronic lymphocytic leukemia (CLL) in the era of B-cell receptor signal transduction inhibitorsA crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activationLocalization of Tec29 to ring canals is mediated by Src64 and PtdIns(3,4,5)P3-dependent mechanisms.Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis.Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells.Sodium and potassium regulate endothelial phospholipase C-γ and Bmx.A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levelsPhosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytesBTK inhibitors in chronic lymphocytic leukemia: a glimpse to the future.Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods.Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism.Adapters in the organization of mast cell signaling.Signalling scaffolds and adaptors in T-cell immunity.The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.Itk: the rheostat of the T cell response.Bruton tyrosine kinase is a therapeutic target in stem-like cells from multiple myelomaExpression of mouse Dab2ip transcript variants and gene methylation during brain development.Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo.p85β phosphoinositide 3-kinase subunit regulates tumor progressionA phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignanciesComputational Analysis of the Binding Specificities of PH Domains.Calcium signalling and cell-fate choice in B cells.The tyrosine kinase network regulating mast cell activation.The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cellsPI3K functions in cancer progression, anticancer immunity and immune evasion by tumors.Role of inositol phospholipid signaling in natural killer cell biology.Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.Bruton's Tyrosine Kinase Inhibitors Prevent Therapeutic Escape in Breast Cancer Cells.Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity.Consequences of two naturally occurring missense mutations in the structure and function of Bruton agammaglobulinemia tyrosine kinase.Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.The lymphoma-associated fusion tyrosine kinase ITK-SYK requires pleckstrin homology domain-mediated membrane localization for activation and cellular transformation.Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway.Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720.
P2860
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P2860
Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Interaction between the Btk PH ...... sphate directly regulates Btk.
@en
type
label
Interaction between the Btk PH ...... sphate directly regulates Btk.
@en
prefLabel
Interaction between the Btk PH ...... sphate directly regulates Btk.
@en
P2093
P2860
P356
P1476
Interaction between the Btk PH ...... sphate directly regulates Btk.
@en
P2093
P2860
P304
16201-16206
P356
10.1074/JBC.M100873200
P407
P577
2001-01-30T00:00:00Z