Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585. - Wikidata - wikimedia - TriplyDB

Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585.

Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585.

http://www.wikidata.org/entity/Q40834224

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Selective Neuromuscular Denervation in Taiwanese Severe SMA Mouse Can Be Reversed by Morpholino Antisense Oligonucleotides The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models.Efficient SMN Rescue following Subcutaneous Tricyclo-DNA Antisense Oligonucleotide Treatment Improvement of neuromuscular synaptic phenotypes without enhanced survival and motor function in severe spinal muscular atrophy mice selectively rescued in motor neurons Histopathological Defects in Intestine in Severe Spinal Muscular Atrophy Mice Are Improved by Systemic Antisense Oligonucleotide Treatment.SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA.Genetic inhibition of JNK3 ameliorates spinal muscular atrophy.Mechanistic principles of antisense targets for the treatment of spinal muscular atrophy Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy.Severe impairment of male reproductive organ development in a low SMN expressing mouse model of spinal muscular atrophy Placental development in a mouse model of spinal muscular atrophy.Decreased function of survival motor neuron protein impairs endocytic pathways.Spinal muscular atrophy: an update on therapeutic progress Survival Motor Neuron (SMN) protein is required for normal mouse liver development.Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy.Cardiac pathology in spinal muscular atrophy: a systematic review.Spinal muscular atrophy: a motor neuron disorder or a multi-organ disease?Diverse role of survival motor neuron protein.How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophy Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy.Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model.Spinal muscular atrophy: antisense oligonucleotide therapy opens the door to an integrated therapeutic landscape.Predominant expression of exon 7 skipped SMN mRNAs in lung based on analysis of transcriptome sequencing datasets.Survival of motor neurone protein is required for normal postnatal development of the spleen.AP-1 confers resistance to anti-cancer therapy by activating XIAP.Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice

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Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585.

http://www.wikidata.org/entity/Q40834224

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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Severe SMA mice show organ imp ...... y with the HDACi JNJ-26481585.

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Severe SMA mice show organ imp ...... y with the HDACi JNJ-26481585.

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Severe SMA mice show organ imp ...... y with the HDACi JNJ-26481585.

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European Journal of Human Genetics

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Severe SMA mice show organ imp ...... y with the HDACi JNJ-26481585.

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Albrecht Berkessel

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Anja Sterner-Kock

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Bastian Ackermann

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Brunhilde Wirth

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Eilidh Somers

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Jan Krämer

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Julia Schreml

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Kristina Roßbach

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Lutz Garbes

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Mario Paterno

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SMA CARNIVAL TRIAL PART II: a prospective, single-armed trial of L-carnitine and valproic acid in ambulatory children with spinal muscular atrophy

SMA CARNI-VAL trial part I: double-blind, randomized, placebo-controlled trial of L-carnitine and valproic acid in spinal muscular atrophy

Drug treatment for spinal muscular atrophy types II and III

Drug treatment for spinal muscular atrophy type I

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition

Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy

Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1

Laparoscopic Nissen fundoplication during gastrostomy tube placement and noninvasive ventilation may improve survival in type I and severe type II spinal muscular atrophy

mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass

The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells

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10.1038/EJHG.2012.222

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6

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21

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