Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells.
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Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individualsDisturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus ErythematosusThe Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T CellsTranscription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunityRETRACTED: Functional activation of proline-rich tyrosine kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.T-cell and B-cell signaling biomarkers and treatment targets in lupus.Estradiol differentially regulates calreticulin: a potential link with abnormal T cell function in systemic lupus erythematosus?IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter.Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis.Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus.Abnormal T cell signal transduction in systemic lupus erythematosus.Dendritic cells under investigation in autoimmune disease.Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro.Intrinsic T cell defects in systemic autoimmunity.Major peptide autoepitopes for nucleosome-centered T and B cell interaction in human and murine lupus.Immunopathology and the gene therapy of lupus.Targeting CD40L: a promising therapeutic approach.T-lymphocyte signalling in systemic lupus erythematosus: a lipid raft perspective.Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus.T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens.Megakaryocyte progenitors are the main APCs inducing Th17 response to lupus autoantigens and foreign antigensLupus autoimmunity altered by cellular methylation metabolism.Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production.Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus.Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupusTuning of CD40-CD154 interactions in human B-lymphocyte activation: a broad array of in vitro models for a complex in vivo situation.Aberrant B-lymphocyte responses in lupus: inherent or induced and potential therapeutic targets.Dendritic cells from lupus-prone mice are defective in repressing immunoglobulin secretion.Altered regulation of IL-2 production in systemic lupus erythematosus: an evolving paradigm.Apigenin, a dietary flavonoid, sensitizes human T cells for activation-induced cell death by inhibiting PKB/Akt and NF-kappaB activation pathway.Expression and function of Cbl-b in T cells from patients with systemic lupus erythematosus, and detection of the 2126 A/G Cblb gene polymorphism in the Mexican mestizo population.Extracellular signal-regulated kinase 1/2 signalling in SLE T cells is influenced by oestrogen and disease activity.Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus.Curcumin modulation of the activation of PYK2 in peripheral blood mononuclear cells from patients with lupus nephritis.Dysregulation of anergy-related factors involved in regulatory T cells defects in Systemic Lupus Erythematosus patients: Rapamycin and Vitamin D efficacy in restoring regulatory T cells.Estrogen does not regulate CD154 mRNA stability in systemic lupus erythematosus T cells.
P2860
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P2860
Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Regulatory defects in Cbl and ...... ligand in human lupus T cells.
@en
type
label
Regulatory defects in Cbl and ...... ligand in human lupus T cells.
@en
prefLabel
Regulatory defects in Cbl and ...... ligand in human lupus T cells.
@en
P2093
P1476
Regulatory defects in Cbl and ...... ligand in human lupus T cells.
@en
P2093
P304
P356
10.4049/JIMMUNOL.165.11.6627
P407
P577
2000-12-01T00:00:00Z