Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death.
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Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factorsPIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersCryptic promoter activity in the DNA sequence corresponding to the pim-1 5'-UTRThe PIM kinases in hematological cancersThe oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpointEvidence that the Pim1 kinase gene is a direct target of HOXA9The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitorPim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cellsPreservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cellsGenomic microarrays: arraying order in biological chaos?Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferationHost microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell deathExpression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase.Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes.IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer in vivo by JAK/STAT-mediated induction of p21.PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis.DYRK3 dual-specificity kinase attenuates erythropoiesis during anemiaThe PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.Potential of mTOR inhibitors as therapeutic agents in hematological malignancies.Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis.Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site.Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection.The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
P2860
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P2860
Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death.
@en
type
label
Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death.
@en
prefLabel
Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death.
@en
P2093
P2860
P356
P1433
P1476
Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203684
P407
P577
2000-07-01T00:00:00Z
P5875
P6179
1021342365