Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity.
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Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutationsDAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expressionMutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney diseaseDefective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitusDiagnosis of HNF-1alpha mutations on a PNA zip-code microarray by single base extensionMaturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?Pathogenesis of the metabolic syndrome: insights from monogenic disordersCrystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligandMonogenic diabetes and pregnancyFoxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin releasePolygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.Maturity-onset diabetes of the young (MODY): a new challenge for pediatric diabetologists.Dissecting the transcriptional network of pancreatic islets during development and differentiation.Hepatocyte nuclear factor 1 alpha (HNF-1 alpha) mutations in maturity-onset diabetes of the young.Review article: the genetics of inflammatory bowel disease.Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.New HNF-1α nonsense mutation causes maturity-onset diabetes of the young type 3.The search for type 2 diabetes susceptibility genes using whole-genome scans: an epidemiologist's perspective.Development and diseases of the pancreas.Genetics of type 2 diabetes and insulin resistance: knowledge from human studies.Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasisPhenotype variability and neonatal diabetes in a large family with heterozygous mutation of the glucokinase gene.Preventing Type 2 diabetes and the dysmetabolic syndrome in the real world: a realistic view.The mutated human gene encoding hepatocyte nuclear factor 1beta inhibits kidney formation in developing Xenopus embryosHnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression.Monogenic models: what have the single gene disorders taught us?Molecular diagnosis of maturity onset diabetes of the young in India.Characteristics of maturity onset diabetes of the young in a large diabetes center.Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.Investigating maturity onset diabetes of the young.Stem cell therapy to treat diabetes mellitus.A likelihood ratio test for genome-wide association under genetic heterogeneity.Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo.When is it MODY? Challenges in the Interpretation of Sequence Variants in MODY Genes.Exploring the role of the HNF-1αG319S polymorphism in β cell failure and youth-onset type 2 diabetes: Lessons from MODY and Hnf-1α-deficient animal models.Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree.Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line.Predictive genetic testing in maturity-onset diabetes of the young (MODY).
P2860
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P2860
Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Maturity-onset diabetes of the ...... ined by genetic heterogeneity.
@en
type
label
Maturity-onset diabetes of the ...... ined by genetic heterogeneity.
@en
prefLabel
Maturity-onset diabetes of the ...... ined by genetic heterogeneity.
@en
P1433
P1476
Maturity-onset diabetes of the ...... ined by genetic heterogeneity.
@en
P2093
Hattersley AT
P356
10.1002/(SICI)1096-9136(199801)15:1<15::AID-DIA562>3.0.CO;2-M
P577
1998-01-01T00:00:00Z