Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction.
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Human metabolism and metabolic interactions of deployment-related chemicalsEvaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC(TM)) SystemExpression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity.Biological therapies in the systemic management of psoriasis: International Consensus Conference.New technologies and screening strategies for hepatotoxicity: use of in vitro models.Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes.Pharmacokinetics and interactions of headache medications, part I: introduction, pharmacokinetics, metabolism and acute treatments.Application of chimeric mice with humanized liver for predictive ADME.In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations.Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathwaysRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Methodologies used to identify and characterize interactions among antiepileptic drugs.Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction.Biomarkers and human hepatocytes.Novel pre-clinical methodologies for pharmacokinetic drug-drug interaction studies: spotlight on "humanized" animal models.Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells.Modulation of Kupffer cells on hepatic drug metabolism.High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1.Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte co-cultures.A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.The effects of fenbendazole, flubendazole and mebendazole on activities of hepatic cytochromes P450 in pig.Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes.In vivo induction of human cytochrome P450 3A4 by rifabutin in chimeric mice with humanized liver.An update on metabolism studies using human hepatocytes in primary culture
P2860
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P2860
Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Preclinical evaluation of drug ...... of cytochrome P450 induction.
@en
type
label
Preclinical evaluation of drug ...... of cytochrome P450 induction.
@en
prefLabel
Preclinical evaluation of drug ...... of cytochrome P450 induction.
@en
P2093
P1476
Preclinical evaluation of drug ...... n of cytochrome P450 induction
@en
P2093
M J Gomez-Lechon
M Jurima-Romet
P356
10.1016/S0009-2797(97)00070-7
P50
P577
1997-11-01T00:00:00Z