Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
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Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanismmTOR is a key modulator of ageing and age-related diseaseThe associations between Parkinson's disease and cancer: the plot thickensErythropoietin: new directions for the nervous systemShedding new light on neurodegenerative diseases through the mammalian target of rapamycinProtein degradation pathways in Parkinson's disease: curse or blessingThe critical roles of mitophagy in cerebral ischemiaPotential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersTherapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New TricksParkinson's disease as a result of agingThe role of mTOR signaling in Alzheimer diseaseTsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagyRTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disordersRTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migrationAlleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegenerationEndogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in miceRapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathyProgressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's diseaseActivation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's diseaseRapamycin is neuroprotective in a rat chronic hypertensive glaucoma model.Expression analysis of dopaminergic neurons in Parkinson's disease and aging links transcriptional dysregulation of energy metabolism to cell death.Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy.Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Rapamycin promotes Schwann cell migration and nerve growth factor secretion.Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model tMitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection.A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.Hot topics in aging research: protein translation and TOR signaling, 2010Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegenerationIntracellular signalling pathways in dopamine cell death and axonal degeneration.A knockout of the caspase 2 gene produces increased resistance of the nigrostriatal dopaminergic pathway to MPTP-induced toxicity.Autophagy regulates colistin-induced apoptosis in PC-12 cells.Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.α-Synuclein levels modulate Huntington's disease in mice.Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition.Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signalingParkinson's disease: don't mess with calcium.The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation
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P2860
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Rapamycin protects against neu ...... models of Parkinson's disease.
@en
type
label
Rapamycin protects against neu ...... models of Parkinson's disease.
@en
prefLabel
Rapamycin protects against neu ...... models of Parkinson's disease.
@en
P2093
P2860
P1476
Rapamycin protects against neu ...... models of Parkinson's disease.
@en
P2093
Cristina Malagelada
Lloyd A Greene
Zong Hao Jin
P2860
P304
P356
10.1523/JNEUROSCI.3944-09.2010
P407
P577
2010-01-01T00:00:00Z