HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis.
about
Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cellsGSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesisAn autoinhibitory effect of the homothorax domain of Meis2Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalonDifferential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1Identification and characterization of Hoxa9 binding sites in hematopoietic cellsConstitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemiaConditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9Pbx3 deficiency results in central hypoventilationDisentangling the many layers of eukaryotic transcriptional regulationStructure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posteriorTALE homeoproteins as HOX11-interacting partners in T-cell leukemiaHuman growth hormone-regulated HOXA1 is a human mammary epithelial oncogenePBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter regionHematopoietic, angiogenic and eye defects in Meis1 mutant animals.p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells.Cooperative transcriptional activation by Klf4, Meis2, and Pbx1High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia.Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemiaNUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice.CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein.Homeobox genes in normal and malignant cells.The TALE homeodomain protein Pbx2 is not essential for development and long-term survivalMicroarray Analysis of Defective Cartilage in Hoxc8- and Hoxd4-Transgenic Mice.Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insightsTransformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.Two isoforms of HOXA9 function differently but work synergistically in human MLL-rearranged leukemia.Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation.Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.TLX1 (HOX11) immortalization of embryonic stem cell-derived and primary murine hematopoietic progenitors.Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancerHOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis.Ecotropic viral integration site 1, stem cell self-renewal and leukemogenesis.Controlling Hox gene expression and activity to build the vertebrate axial skeleton.Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes.Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells.miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia.
P2860
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P2860
HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
HoxA9-mediated immortalization ...... h TALE cofactors Pbx and Meis.
@en
type
label
HoxA9-mediated immortalization ...... h TALE cofactors Pbx and Meis.
@en
prefLabel
HoxA9-mediated immortalization ...... h TALE cofactors Pbx and Meis.
@en
P2093
P2860
P356
P1433
P1476
HoxA9-mediated immortalization ...... h TALE cofactors Pbx and Meis.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203371
P407
P577
2000-02-01T00:00:00Z
P5875
P6179
1047740194