Processing of cyclin E differs between normal and tumor breast cells.
about
A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapyChromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cellsLow-molecular-weight cyclin E: the missing link between biology and clinical outcomeHigh cyclin E staining index in blastemal, stromal or epithelial cells is correlated with tumor aggressiveness in patients with nephroblastoma.Cold-inducible RNA-binding protein contributes to human antigen R and cyclin E1 deregulation in breast cancer.siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model.Novel splice variants of cyclin E with altered substrate specificity.Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight formsA novel interaction between HER2/neu and cyclin E in breast cancer.LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patientsToo much cleavage of cyclin E promotes breast tumorigenesis.Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells.An intron-retaining splice variant of human cyclin A2, expressed in adult differentiated tissues, induces a G1/S cell cycle arrest in vitro.Divergent behavior of cyclin E and its low molecular weight isoforms to progesterone-induced growth inhibition in MCF-7 cells.CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.Three-dimensional collagen represses cyclin E1 via β1 integrin in invasive breast cancer cells.The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.Altered subcellular localization of tumor-specific cyclin E isoforms affects cyclin-dependent kinase 2 complex formation and proteasomal regulation.Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells.Targeting low molecular weight cyclin E (LMW-E) in breast cancer.Adenovirus E1B55K region is required to enhance cyclin E expression for efficient viral DNA replication.Expression of cyclin D1 and cyclin E in urothelial bladder carcinoma detected in tissue chips using a quantum dot immunofluorescence technique.
P2860
Q24538802-C04A0E87-1713-42AF-A371-70AC6B2820DFQ24806268-AE5756CE-D480-4EBF-ADCD-297CA0205419Q24806316-8726CA9F-1623-4223-968E-A472166E94C3Q33336382-30C4759F-654F-4AFA-BEBD-6AF6DAA01271Q33618433-DD0FB4B0-689B-4577-AE03-D6E52A08EB3EQ33705021-43428FBD-2DD3-4162-9FAB-6112D41693A4Q33855990-D4C31777-03E4-4822-854F-606458255199Q33969505-D43A5136-80E7-4DD7-85B7-FAD4D65E6F11Q33976264-04C88F02-9042-4B81-BC9D-1E3801DEE5FDQ34220979-DAD25AFA-B4D1-46B5-8573-55FF0368A4ACQ34221065-E1055B0D-8FE0-4653-80DB-7E33BA657DA7Q34275891-692EED0B-072A-4C49-911A-9946E6AD829DQ34321288-E6CC009C-BE3C-4EA5-80C2-AF740D01FC68Q34990893-A5C91E84-A1A0-4CA5-8563-ADB39ADD232BQ36778274-29D9D4CE-7884-4228-95BF-ABB702F98FCAQ36792659-A2810F16-07A4-486C-A1E3-590857B9B4EEQ37018880-4787CECF-4D4E-453A-8208-22ED4B6CD6F9Q37160444-9AD0F4BA-AA28-4ECE-9C5D-329A79BEB8CAQ37172133-A17F0D99-6242-4E36-B362-670FB47E1A2CQ37373562-67CA6725-9543-43DA-9902-95465FEE3BEFQ40018751-A5F66F48-9C5C-4BAC-88A4-568BD901436CQ41840776-20DB25CE-07FA-4599-9FD6-4058A0B12F52
P2860
Processing of cyclin E differs between normal and tumor breast cells.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Processing of cyclin E differs between normal and tumor breast cells.
@en
type
label
Processing of cyclin E differs between normal and tumor breast cells.
@en
prefLabel
Processing of cyclin E differs between normal and tumor breast cells.
@en
P2093
P1433
P1476
Processing of cyclin E differs between normal and tumor breast cells.
@en
P2093
P304
P407
P577
2000-01-01T00:00:00Z