Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties.
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Porcine islet amyloid polypeptide fragments are refractory to amyloid formationA hIAPP-derived all-D-amino-acid inhibits hIAPP fibrillation efficiently at membrane surface by targeting α-helical oligomeric intermediatesThe 3D profile method for identifying fibril-forming segments of proteinsStructures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopyMolecular basis for insulin fibril assemblySequence determinants of protein aggregation: tools to increase protein solubility.The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPPMapping the conformational dynamics and pathways of spontaneous steric zipper Peptide oligomerizationAtomic structure of the cross-β spine of islet amyloid polypeptide (amylin)Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: implications for the study of amyloid formationFormation of partially ordered oligomers of amyloidogenic hexapeptide (NFGAIL) in aqueous solution observed in molecular dynamics simulations.The role of Phe in the formation of well-ordered oligomers of amyloidogenic hexapeptide (NFGAIL) observed in molecular dynamics simulations with explicit solvent.Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet CoreAggregation properties of a short peptide that mediates amyloid fibril formation in model proteins unrelated to disease.Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.Sequence determinants of amyloid fibril formationSynthesis and structural investigations of N-alkylated beta-peptidosulfonamide-peptide hybrids of the amyloidogenic amylin(20-29) sequence: Implications of supramolecular folding for the design of peptide-based bionanomaterials.Peptide-peptide interactions between human transferrin and transferrin-binding protein B from Moraxella catarrhalisStructural elements regulating amyloidogenesis: a cholinesterase model system.Self-assembly of peptides to nanostructures.Molecular basis for amyloid fibril formation and stability.New insights into the molecular mechanism of amyloid formation from cysteine scanning.Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: significant role of Asn ladder.Aromaticity and amyloid formation: effect of π-electron distribution and aryl substituent geometry on the self-assembly of peptides derived from hIAPP(22-29).Intersheet rearrangement of polypeptides during nucleation of {beta}-sheet aggregates.The amyloid stretch hypothesis: recruiting proteins toward the dark sideShort peptide amyloid organization: stabilities and conformations of the islet amyloid peptide NFGAILThe stability and dynamics of the human calcitonin amyloid peptide DFNKFStabilities and conformations of Alzheimer's beta -amyloid peptide oligomers (Abeta 16-22, Abeta 16-35, and Abeta 10-35): Sequence effects.Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesisA systematic screen of beta(2)-microglobulin and insulin for amyloid-like segmentsResveratrol inhibits the formation of multiple-layered β-sheet oligomers of the human islet amyloid polypeptide segment 22-27Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry.Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.Peptide amyloid surface display.Phenol red interacts with the protofibril-like oligomers of an amyloidogenic hexapeptide NFGAIL through both hydrophobic and aromatic contacts.Specific pools of endogenous peptides are present in gametophore, protonema, and protoplast cells of the moss Physcomitrella patens.Two-dimensional sum-frequency generation (2D SFG) spectroscopy: summary of principles and its application to amyloid fiber monolayers.Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies
P2860
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P2860
Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Identification of a penta- and ...... enic and cytotoxic properties.
@en
type
label
Identification of a penta- and ...... enic and cytotoxic properties.
@en
prefLabel
Identification of a penta- and ...... enic and cytotoxic properties.
@en
P2093
P356
P1476
Identification of a penta- and ...... enic and cytotoxic properties.
@en
P2093
Bergmann M
Bernhagen J
Kapurniotu A
P304
P356
10.1006/JMBI.1999.3422
P407
P577
2000-01-01T00:00:00Z