Mutant human alpha(1)beta(1)(T262Q) GABA(A) receptors are directly activated but not modulated by pentobarbital.
about
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channelsModulation of GABA(A) receptor channel gating by pentobarbitalNew insights into the molecular mechanisms of general anaesthetics.Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation.General anesthetics have additive actions on three ligand gated ion channels.Pentobarbital produces activation and block of {alpha}1{beta}2{gamma}2S GABAA receptors in rapidly perfused whole cells and membrane patches: divergent results can be explained by pharmacokineticsA single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation.The general anesthetic pentobarbital slows desensitization and deactivation of the glycine receptor in the rat spinal dorsal horn neurons.Anesthetic and ethanol effects on spontaneously opening glycine receptor channels.Conductance of GABAA channels activated by pentobarbitone in hippocampal neurons from newborn rats.
P2860
Q28237504-0D009915-A155-4BB3-9324-A8C26AE9AC1FQ28366489-4B847B3D-54A1-43B1-A62B-4FF1F43D9BD0Q37782116-C8BBB0D9-6DCB-4683-A5F8-C8A3B76C14BFQ40579350-213E2468-1E72-45C7-BB9C-C6EF53353FE0Q41335341-F1A09A72-B2F6-42E4-9AF2-D02A8546FFF1Q42014137-EB582043-7354-48F4-BA20-FEC6409926D5Q42606895-EA90435E-4E3C-4248-B73F-D1D30291072DQ44114979-D1111FB1-4D03-4078-AA0B-F6886017F938Q44158563-6BD56615-FEFC-4B67-ACEC-0135781B6931Q44535859-E021B7BA-1CA2-41EB-B573-178C37181012
P2860
Mutant human alpha(1)beta(1)(T262Q) GABA(A) receptors are directly activated but not modulated by pentobarbital.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Mutant human alpha(1)beta(1)(T ...... ot modulated by pentobarbital.
@en
type
label
Mutant human alpha(1)beta(1)(T ...... ot modulated by pentobarbital.
@en
prefLabel
Mutant human alpha(1)beta(1)(T ...... ot modulated by pentobarbital.
@en
P2093
P1476
Mutant human alpha(1)beta(1)(T ...... ot modulated by pentobarbital.
@en
P2093
P304
P356
10.1016/S0014-2999(99)00710-4
P407
P577
1999-12-01T00:00:00Z