Characterization and properties of dominant-negative mutants of the ras-specific guanine nucleotide exchange factor CDC25(Mm).
about
Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts.Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia.Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.Systems biology and the molecular circuits of cancer.Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodelingApproaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present).Activation of amyloid precursor protein processing by growth factors is dependent on Ras GTPase activity.The isolated catalytic hairpin of the Ras-specific guanine nucleotide exchange factor Cdc25Mm retains nucleotide dissociation activity but has impaired nucleotide exchange activity.A dominant negative RAS-specific guanine nucleotide exchange factor reverses neoplastic phenotype in K-ras transformed mouse fibroblasts.Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange.Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.
P2860
Q33415058-96C70A11-F43E-4777-846E-AA8924A34481Q33758221-3B678D73-1259-43F0-B6AF-2D9A76501AD7Q35458543-99F98126-54E0-4C56-AE8E-923E3E0CD506Q35905281-5F3D76A9-7588-4A3D-80A5-8019C170EC3EQ36228895-C94240F0-9CFF-4FB4-9940-2B5D80C1C9D1Q38046230-A86B9D40-A4C9-4ACB-9EBE-355B5FF675D5Q39619549-0A2B7975-F981-477D-B552-DA88FED32CC0Q40344201-FA8B6E13-40BE-4CB4-B5A2-CDFA9537AB03Q40879246-8E8FB19B-5815-4C00-9C44-506BDFEABAC8Q43595428-0CD3A684-A0A3-4E0F-9E92-2BEC3DC08FB9Q44100841-7BBC0C7D-AA81-472A-9481-10D92701E37B
P2860
Characterization and properties of dominant-negative mutants of the ras-specific guanine nucleotide exchange factor CDC25(Mm).
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Characterization and propertie ...... ide exchange factor CDC25(Mm).
@en
type
label
Characterization and propertie ...... ide exchange factor CDC25(Mm).
@en
prefLabel
Characterization and propertie ...... ide exchange factor CDC25(Mm).
@en
P2093
P2860
P50
P356
P1476
Characterization and propertie ...... tide exchange factor CDC25(Mm)
@en
P2093
A Colagrande
C Bizzarri
L Fontanella
M Cattozzo
V Sabbatini
P2860
P304
36656-36662
P356
10.1074/JBC.274.51.36656
P407
P577
1999-12-01T00:00:00Z