Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25.
about
Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiaeIdentification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiaeC3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteinsA novel role for RhoGDI as an inhibitor of GAP proteinsRegulation of small GTPases by GEFs, GAPs, and GDIsTfs1p, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces cerevisiaeAnalysis of the role of the hypervariable region of yeast Ras2p and its farnesylation in the interaction with exchange factors and adenylyl cyclase.SDC25, a CDC25-like gene which contains a RAS-activating domain and is a dispensable gene of Saccharomyces cerevisiae.Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function.Involvement of a small GTP-binding protein (G protein) regulator, small G protein GDP dissociation stimulator, in antiapoptotic cell survival signalingRas history: The saga continues.Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange proteinCloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator.Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway.A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium.Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein.Residues crucial for Ras interaction with GDP-GTP exchangers.The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17.Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins.Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.SDC25, a dispensable Ras guanine nucleotide exchange factor of Saccharomyces cerevisiae differs from CDC25 by its regulation.GTPase domains of ras p21 oncogene protein and elongation factor Tu: analysis of three-dimensional structures, sequence families, and functional sitesRas and Rho small G proteins: insights from the Schizophyllum commune genome sequence and comparisons to other fungi.The cellular content of Cdc25p, the Ras exchange factor in Saccharomyces cerevisiae, is regulated by destabilization through a cyclin destruction box.Switching nucleotide specificity of Ha-Ras p21 by a single amino acid substitution at aspartate 119.The Saccharomyces cerevisiae CDC25 gene product binds specifically to catalytically inactive ras proteins in vivo.Mutational analysis of the putative effector domain of the GTP-binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity.Guanyl nucleotide exchange factor Sql2 and Ras2 regulate filamentous growth in Ustilago maydis.Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTPRSR1, a ras-like gene homologous to Krev-1 (smg21A/rap1A): role in the development of cell polarity and interactions with the Ras pathway in Saccharomyces cerevisiaeMultimeric threading-based prediction of protein-protein interactions on a genomic scale: application to the Saccharomyces cerevisiae proteome.Characterization and properties of dominant-negative mutants of the ras-specific guanine nucleotide exchange factor CDC25(Mm).RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP.Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras.Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factorsThe CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.Yeast alpha-mating factor receptor-linked G-protein signal transduction suppresses Ras-dependent activity.Myristoylation-facilitated binding of the G protein ARF1GDP to membrane phospholipids is required for its activation by a soluble nucleotide exchange factor.Mutations at position 1122 in the catalytic domain of the mouse ras-specific guanine nucleotide exchange factor CDC25Mm originate both loss-of-function and gain-of-function proteins.
P2860
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P2860
Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25.
description
1990 nî lūn-bûn
@nan
1990 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@ast
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@en
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@nl
type
label
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@ast
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@en
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@nl
prefLabel
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@ast
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@en
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@nl
P2093
P356
P1433
P1476
Enhancement of the GDP-GTP exc ...... oxyl-terminal domain of SCD25.
@en
P2093
A Parmeggiani
E Boy-Marcotte
J B Créchet
M Y Mistou
P356
10.1126/SCIENCE.2188363
P407
P577
1990-05-18T00:00:00Z