Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism.
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The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosaInhibitor of cyclooxygenase-2 induces cell-cycle arrest in the epithelial cancer cell line via up-regulation of cyclin dependent kinase inhibitor p21Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis.Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer.Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data from randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01).Cytotoxic necrotizing factor from Escherichia coli induces RhoA-dependent expression of the cyclooxygenase-2 Gene.Uterine leiomyomas express myometrial contractile-associated proteins involved in pregnancy-related hormone signaling.P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosisCOX-2 - a target for preventing hepatic carcinoma?Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration.Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assayExpression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma.Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: possible role in tumor promotion and angiogenesis.COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activationMolecular mechanisms of pancreatic cancer and potential targets of treatment.Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism.Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1β-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells.Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile.Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol.Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis.Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells.Inhibition of platelet-derived growth factor-induced mesangial cell proliferation by cyclooxygenase-2 overexpression is abolished through reactive oxygen species.Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis.Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells.Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase.Genomic, Lipidomic and Metabolomic Analysis of Cyclooxygenase-null Cells: Eicosanoid Storm, Cross Talk, and Compensation by COX-1.Cyclooxygenases in hepatocellular carcinoma.Up-regulation of cyclooxygenase-1 in neuroblastoma cell lines by retinoic acid and corticosteroids.NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines.Proteomic Analysis Shows Constitutive Secretion of MIF and p53-associated Activity of COX-2-/- Lung Fibroblasts.Dynamics of nuclear localization sites for COX-2 in vascular endothelial cells.
P2860
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P2860
Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Overexpression of cyclooxygena ...... glandin-independent mechanism.
@en
type
label
Overexpression of cyclooxygena ...... glandin-independent mechanism.
@en
prefLabel
Overexpression of cyclooxygena ...... glandin-independent mechanism.
@en
P2093
P2860
P356
P1476
Overexpression of cyclooxygena ...... glandin-independent mechanism.
@en
P2093
B D Thompson
O C Trifan
P2860
P304
34141-34147
P356
10.1074/JBC.274.48.34141
P407
P50
P577
1999-11-01T00:00:00Z