Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis.
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Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activityMOZ increases p53 acetylation and premature senescence through its complex formation with PMLThe PI3K-PDK1 connection: more than just a road to PKBDirect, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damageCaspase-3 promotes genetic instability and carcinogenesis.Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1AlphaRedefining the roles of apoptotic factors in carcinogenesisPTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit.Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis.Modeling the response of a tumor-suppressive network to mitogenic and oncogenic signals.A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleusG Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery.Apoptosis and liver diseases: recent concepts of mechanism and significance.Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action.Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signalsOncogenic viruses and tumor glucose metabolism: like kids in a candy store.Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt.Basal Protein Expression Is Associated With Worse Outcome and Trastuzamab Resistance in HER2+ Invasive Breast Cancer.p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKBAkt regulates cell survival and apoptosis at a postmitochondrial levelAccumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells.The microtubule as a breast cancer target.Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer.2,4-bis (p-hydroxyphenyl)-2-butenal (HPB242) induces apoptosis via modulating E7 expression and inhibition of PI3K/Akt pathway in SiHa human cervical cancer cells.E5 protein of human papillomavirus type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis.p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas.Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.Downregulation of wild-type p53 protein by HER-2/neu mediated PI3K pathway activation in human breast cancer cells: its effect on cell proliferation and implication for therapy.UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cytochrome c resistance.Role of DDC-4/sFRP-4, a secreted frizzled-related protein, at the onset of apoptosis in mammary involution.The role of PI 3-kinase in the UVB-induced expression of c-fos.PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity.Activation of the phosphatidylinositol 3-kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis.Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition.Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells.Different cellular localization, translocation, and insulin-induced phosphorylation of PKBalpha in HepG2 cells and hepatocytes.
P2860
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P2860
Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Phosphoinositide 3-OH kinase ( ...... ptionally dependent apoptosis.
@en
type
label
Phosphoinositide 3-OH kinase ( ...... ptionally dependent apoptosis.
@en
prefLabel
Phosphoinositide 3-OH kinase ( ...... ptionally dependent apoptosis.
@en
P2860
P356
P1476
Phosphoinositide 3-OH kinase ( ...... ptionally dependent apoptosis.
@en
P2093
McCormick F
Sabbatini P
P2860
P304
24263-24269
P356
10.1074/JBC.274.34.24263
P407
P577
1999-08-01T00:00:00Z