ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit.
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Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2The carboxyl termini of K(ATP) channels bind nucleotidesNovel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces.Engineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutationsMolecular diversity and regulation of renal potassium channels.Nucleotides and phospholipids compete for binding to the C terminus of KATP channels.KATP channels gated by intracellular nucleotides and phospholipids.The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATPMolecular basis for Kir6.2 channel inhibition by adenine nucleotides.Concerted gating mechanism underlying KATP channel inhibition by ATP.ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transferStructurally distinct ligands rescue biogenesis defects of the KATP channel complex via a converging mechanism.Mechanism of KATP hyperactivity and sulfonylurea tolerance due to a diabetogenic mutation in L0 helix of sulfonylurea receptor 1 (ABCC8)Gating mechanism of KATP channels: function fits form.Glucose-sensing mechanisms in pancreatic beta-cells.Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels.The role of NH2-terminal positive charges in the activity of inward rectifier KATP channelsSulfonylurea and K(+)-channel opener sensitivity of K(ATP) channels. Functional coupling of Kir6.2 and SUR1 subunitsPhosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibitionOpen state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP.Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channelDominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.Risk loci for type 2 diabetes - quo vadis?The diabetic β-cell: hyperstimulated vs. hyperexcited.Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus.Identification of residues contributing to the ATP binding site of Kir6.2.Incomplete dissociation of glibenclamide from wild-type and mutant pancreatic K ATP channels limits their recovery from inhibition.Analysis of two KCNJ11 neonatal diabetes mutations, V59G and V59A, and the analogous KCNJ8 I60G substitution: differences between the channel subtypes formed with SUR1.ATP-sensitive K+ channels: regulation of bursting by the sulphonylurea receptor, PIP2 and regions of Kir6.2.A region of the sulfonylurea receptor critical for a modulation of ATP-sensitive K(+) channels by G-protein betagamma-subunits.Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP.Membrane topology of the amino-terminal region of the sulfonylurea receptor.The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.Mechanism of Kir6.2 channel inhibition by sulfhydryl modification: pore block or allosteric gating?Contractility and ischemic response of hearts from transgenic mice with altered sarcolemmal K(ATP) channels.Regulation of action potential duration under acute heat stress by I(K,ATP) and I(K1) in fish cardiac myocytes.Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels.Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation.
P2860
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P2860
ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
ATP inhibition of KATP channel ...... domain of the Kir6.2 subunit.
@en
type
label
ATP inhibition of KATP channel ...... domain of the Kir6.2 subunit.
@en
prefLabel
ATP inhibition of KATP channel ...... domain of the Kir6.2 subunit.
@en
P2093
P2860
P1476
ATP inhibition of KATP channel ...... domain of the Kir6.2 subunit.
@en
P2093
P2860
P356
10.1111/J.1469-7793.1999.019AD.X
P407
P478
515 ( Pt 1)
P577
1999-02-01T00:00:00Z