Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. - Wikidata - wikimedia - TriplyDB

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling.

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling.

http://www.wikidata.org/entity/Q40990146

about

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR Antiviral actions of interferons Rubella virus replication and links to teratogenicity Modular structure of PACT: distinct domains for binding and activating PKR Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action Oncogenes: The Passport for Viral Oncolysis Through PKR Inhibition Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's Disease Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis Internal ribosome entry segment-mediated initiation of c-Myc protein synthesis following genotoxic stress The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells Proapoptotic protein PACT is expressed at high levels in colonic epithelial cells in mice Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice P58(IPK): a novel "CIHD" member of the host innate defense response against pathogenic virus infection.The Rela(p65) subunit of NF-kappaB is essential for inhibiting double-stranded RNA-induced cytotoxicity.Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound.Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300.Vesicular stomatitis viruses expressing wild-type or mutant M proteins activate apoptosis through distinct pathways.Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling.Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity.Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway The IRF-3 transcription factor mediates Sendai virus-induced apoptosis Role of p58IPK in Endoplasmic Reticulum Stress-associated Apoptosis and Inflammation dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication.Matrix protein and another viral component contribute to induction of apoptosis in cells infected with vesicular stomatitis virus.

P2860

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P2860

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling.

http://www.wikidata.org/entity/Q40990146

description

1998 nî lūn-bûn

@nan

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

1998年论文

@zh

1998年论文

@zh-cn

name

Activation of the dsRNA-depend ...... FADD-mediated death signaling.

@en

type

label

Activation of the dsRNA-depend ...... FADD-mediated death signaling.

@en

prefLabel

Activation of the dsRNA-depend ...... FADD-mediated death signaling.

@en

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The EMBO Journal

P1476

Activation of the dsRNA-depend ...... FADD-mediated death signaling.

@en

P2093

C N Kim

http://www.w3.org/2001/XMLSchema#string

G N Barber

http://www.w3.org/2001/XMLSchema#string

K Bhalla

http://www.w3.org/2001/XMLSchema#string

S Balachandran

http://www.w3.org/2001/XMLSchema#string

T W Mak

http://www.w3.org/2001/XMLSchema#string

W C Yeh

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

P304

6888-6902

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10.1093/EMBOJ/17.23.6888

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23

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1998-12-01T00:00:00Z

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13443231

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P698

9843495

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P921

PKR signal transduction

P932

1171037

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