APOE genotype alters glial activation and loss of synaptic markers in mice - Wikidata - wikimedia - TriplyDB

APOE genotype alters glial activation and loss of synaptic markers in mice

APOE genotype alters glial activation and loss of synaptic markers in mice

http://www.wikidata.org/entity/Q40998426

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ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2 Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration Genetics ignite focus on microglial inflammation in Alzheimer's disease Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Protective effects of APOE e2 against disease progression in subcortical vascular mild cognitive impairment patients: A three-year longitudinal study.Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs.Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits Two Alzheimer's disease risk genes increase entorhinal cortex volume in young adults CNF1 increases brain energy level, counteracts neuroinflammatory markers and rescues cognitive deficits in a murine model of Alzheimer's disease.Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease.Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia.Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease.Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease.Identification and modification of amyloid-independent phenotypes of APOE4 mice A phenotypic change but not proliferation underlies glial responses in Alzheimer disease Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer's disease in vitro APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice.Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.Cognitive deficits and disruption of neurogenesis in a mouse model of apolipoprotein E4 domain interaction Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease.The E. coli CNF1 as a pioneering therapy for the central nervous system diseases.ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.The role of APOE on lipid homeostasis and inflammation in normal brains.ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function.Apolipoprotein E-ε4 deficiency and cognitive function in hepatitis C virus-infected patients.Effect of APOE Genotype on Synaptic Proteins in Earlier Adult Life.ERβ and ApoE isoforms interact to regulate BDNF-5-HT2A signaling and synaptic function in the female brain.APOE3, but not APOE4, bone marrow transplantation mitigates behavioral and pathological changes in a mouse model of Alzheimer disease APOE genotype-dependent modulation of astrocyte chemokine CCL3 production.Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.Synapses in neurodegenerative diseases.

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P2860

APOE genotype alters glial activation and loss of synaptic markers in mice

http://www.wikidata.org/entity/Q40998426

description

2012 nî lūn-bûn

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2012年の論文

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2012年论文

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2012年论文

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2012年论文

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name

APOE genotype alters glial activation and loss of synaptic markers in mice

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APOE genotype alters glial activation and loss of synaptic markers in mice

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APOE genotype alters glial activation and loss of synaptic markers in mice

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APOE genotype alters glial activation and loss of synaptic markers in mice

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Chunjiang Yu

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Evelyn Nwabuisi-Heath

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G William Rebeck

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Leon M Tai

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Mary Jo LaDu

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Sonya B Dumanis

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Yuangui Zhu

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P2860

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury

Isoform-specific binding of apolipoprotein E to beta-amyloid

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

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10.1002/GLIA.22289

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