Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression.
about
Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcriptionA novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadismPathways of Egr-1-mediated gene transcription in vascular biologySF-1 a key player in the development and differentiation of steroidogenic tissuesTpit determines alternate fates during pituitary cell differentiationEarly growth response gene-1 regulates the expression of the rat luteinizing hormone receptor geneNuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta geneStress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells.NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo.Regulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent.Pituitary homeobox 2 regulates adrenal4 binding protein/steroidogenic factor-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancerIdentification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays.Cross talk in hormonally regulated gene transcription through induction of estrogen receptor ubiquitylation.An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation.Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements.Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRHTissue-specific expression of squirrel monkey chorionic gonadotropin.The expression of the follicle-stimulating hormone receptor in spermatogenesis.A FTZ-F1-containing yeast artificial chromosome recapitulates expression of steroidogenic factor 1 in vivo.Expression of steroidogenic factor 1 in the testis requires an interactive array of elements within its proximal promoter.Expression of steroidogenic factor 1 in the testis requires an E box and CCAAT box in its promoter proximal region.Candidate genes for panhypopituitarism identified by gene expression profiling.Activity of the porcine gonadotropin-releasing hormone receptor gene promoter is partially conferred by a distal gonadotrope specific element (GSE) within an upstream enhancing region, two proximal GSEs and a retinoid X receptor binding site.Cold-shock-domain protein A (CSDA) contributes posttranscriptionally to gonadotropin-releasing hormone-regulated expression of Egr1 and indirectly to Lhb.Heterozygous missense mutations in steroidogenic factor 1 (SF1/Ad4BP, NR5A1) are associated with 46,XY disorders of sex development with normal adrenal function.Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone.Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit geneThe forkhead transcription factor, FOXP3, is required for normal pituitary gonadotropin expression in miceInsulin augments GnRH-stimulated LHbeta gene expression by Egr-1GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICERGnRH pulse frequency-dependent stimulation of FSHβ transcription is mediated via activation of PKA and CREBMolecular physiology of pituitary development: signaling and transcriptional networks.Welcoming beta-catenin to the gonadotropin-releasing hormone transcriptional network in gonadotropesSUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation.Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression.Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription.GnRH-Induced Ca(2+) Signaling Patterns and Gonadotropin Secretion in Pituitary Gonadotrophs. Functional Adaptations to Both Ordinary and Extraordinary Physiological Demands.Conservation of mechanisms mediating gonadotrophin-releasing hormone 1 stimulation of human luteinizing hormone beta subunit transcription.A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene.Identification and characterization of the promoter of fibroblast activation protein.
P2860
Q24554519-C3CD964D-078C-45EB-A19C-113B821DC83FQ24621014-BBA09570-A1DA-4512-BD98-4F1414DB67F6Q24671655-38BF7496-F9AC-4D87-9C03-2AF6C618E78CQ24805943-AE005F4D-B7CA-4098-A311-26C77449426EQ28508185-ADDE5D38-8856-472D-8325-F9E4A6B39456Q28567538-A75ED0CB-5597-4757-B0B0-E998D4447FD5Q28591693-5C25A2A8-D4AD-461F-A0E0-7E1F75000BAEQ30416998-08C31CCD-EC65-4A38-816D-82F8F534E21FQ30421749-D304CDB4-4CE2-4861-A915-B7643F171B53Q30433936-663ED810-D6DA-4737-97FE-EC3DAFE918DDQ33642681-1EEAB4E5-387A-4C14-A033-74D73AFD0100Q33922600-FC749701-2CF4-4C24-9A59-A68D49B9922AQ33924996-EFC7FC36-D7D1-4B85-A258-64737EA05ECBQ34099931-F98BE8D8-4F80-42C7-9478-E43023150E17Q34099993-28B6A3E7-78EA-4F0E-B095-45654DE98DC6Q34100004-A3F9B6C7-70B5-492D-BEA8-2DA855BEE0FEQ34496593-C868ED67-C718-4A30-9277-DFFAF2CEFAC9Q34643912-720E4B37-38B9-4AF0-A300-A52D3CA0426CQ34984887-BA432CDE-0011-4E10-8999-426E784C446DQ35062111-2833548C-F282-4095-9FE8-FFAB3808449FQ35062115-E49445A8-25FD-439B-8539-EFA1289170A9Q35553223-EECFCCA3-7D33-447C-B40C-7EFA69C885DAQ35709726-FC624207-E201-4AEB-BB19-FF98166FA5E4Q35791015-1B7BE5CD-F60E-48CF-840C-EBE5C18AE3C4Q35800939-A9853311-5F74-4487-87B5-C3BC55E00961Q35857010-18A1A515-5417-4C48-A02D-B59E69532E67Q35948308-A586F028-DD7F-4EEE-8DC3-01144A9051FEQ36000638-0C7D87B8-DD9D-462C-922D-B1441D272982Q36297556-0F79FE10-B8A9-4488-8002-259583F50012Q36632415-DA87BA1B-17B5-4767-B071-5286477BCC1AQ36714895-12CF6806-9671-4C42-8C9B-BA23A1E44116Q36872219-7E4BE8B4-A49B-4280-A5C2-BD38ECCCADE5Q37064716-58656779-694C-47EE-A95B-31DB6FBD03A6Q37072165-C38B226D-034F-4696-8E6D-CD029677AA13Q37166045-9C49E90E-E5E7-4E0E-A15F-F22747E6A44DQ37184202-4A5A8526-BFF0-4BC7-9F2A-C20A9B041FD1Q37205553-F840FEE2-64D4-4862-9C84-52606121CB0CQ37324409-FCDB66E0-C662-44B3-99CE-E24DB19D4A16Q38313974-28A6D71B-8748-46DB-9501-7145362DFC90Q38343606-E2305742-9569-4863-84FF-F33728B70A9F
P2860
Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Steroidogenic factor-1 and ear ...... beta-subunit gene expression.
@en
type
label
Steroidogenic factor-1 and ear ...... beta-subunit gene expression.
@en
prefLabel
Steroidogenic factor-1 and ear ...... beta-subunit gene expression.
@en
P2093
P2860
P356
P1476
Steroidogenic factor-1 and ear ...... e beta-subunit gene expression
@en
P2093
P2860
P304
14712-14720
P356
10.1074/JBC.273.24.14712
P407
P577
1998-06-01T00:00:00Z