about
Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptorX-linked sex-determining region Y box 3 (SOX3) gene mutations are uncommon in men with idiopathic oligoazoospermic infertilityNuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis developmentDax1 is required for testis determinationFoxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alphaBlockage of the rete testis and efferent ductules by ectopic Sertoli and Leydig cells causes infertility in Dax1-deficient male miceDistinct roles for steroidogenic factor 1 and desert hedgehog pathways in fetal and adult Leydig cell developmentSteroidogenic factor-1 (SF-1)-driven differentiation of murine embryonic stem (ES) cells into a gonadal lineageEstrogen actions in the male reproductive system involve estrogen response element-independent pathways.Classical estrogen receptor alpha signaling mediates negative and positive feedback on gonadotropin-releasing hormone neuron firingEstrogen receptor alpha signaling pathways differentially regulate gonadotropin subunit gene expression and serum follicle-stimulating hormone in the female mouseSplice variants of the forkhead box protein AFX exhibit dominant negative activity and inhibit AFXalpha-mediated tumor cell apoptosis.2014 Association of American Physicians Presidential Address. Disruptive innovation as a driver of science and medicineThe imperative to invest in science has never been greater.A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics.Inherited disorders of the gonadotropin hormones.Sox3 functions in a cell-autonomous manner to regulate spermatogonial differentiation in mice.Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from SmadSF1 in the development of the adrenal gland and gonads.Heterozygous missense mutations in steroidogenic factor 1 (SF1/Ad4BP, NR5A1) are associated with 46,XY disorders of sex development with normal adrenal function.ENU mutagenesis in mice identifies candidate genes for hypogonadismMinireview: transcriptional regulation of gonadal development and differentiation.Rites of passage through puberty: a complex genetic ensembleQuantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat.Introduction of John T. Potts JrClassification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.ERE-independent ERalpha target genes differentially expressed in human breast tumors.Phenotypic features associated with mutations in steroidogenic acute regulatory protein.Aromatase promoter I.f is regulated by estrogen receptor alpha (ESR1) in mouse hypothalamic neuronal cell lines.Nonhomologous end-joining ligation transfers DNA regulatory elements between cointroduced plasmids.Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements.Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest.Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2.Dominant negative ER induces apoptosis in GH(4) pituitary lactotrope cells and inhibits tumor growth in nude mice.Mutant vasopressin precursors that cause autosomal dominant neurohypophyseal diabetes insipidus retain dimerization and impair the secretion of wild-type proteins.Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression.Second zinc finger mutants of thyroid hormone receptor selectively preserve DNA binding and heterodimerization but eliminate transcriptional activation.Gonadotropin-releasing hormone stimulates glycoprotein hormone alpha-subunit messenger ribonucleic acid (mRNA) levels in alpha T3 cells by increasing transcription and mRNA stability.Development of a bioassay for FSH using a recombinant human FSH receptor and a cAMP responsive luciferase reporter gene.
P50
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P50
description
Forscher
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chercheur
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investigador
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researcher
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研究者
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name
James L. Jameson
@en
Jameson JL
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Jameson JL
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Jameson JL
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type
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James L. Jameson
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Jameson JL
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Jameson JL
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Jameson JL
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Jameson JL
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James L. Jameson
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Jameson JL
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Jameson JL
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Jameson JL
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P31
P496
0000-0001-9538-4059