SF3B1 association with chromatin determines splicing outcomes.
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The RNA Splicing Response to DNA DamageEmerging concepts of epigenetic dysregulation in hematological malignanciesDefective control of pre-messenger RNA splicing in human diseaseHow do messenger RNA splicing alterations drive myelodysplasia?A Broad Set of Chromatin Factors Influences SplicingGlobal analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A.Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)Vemurafenib-resistant BRAF selects alternative branch points different from its wild-type BRAF in intron 8 for RNA splicing.The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.Small Molecule Modulators of Pre-mRNA Splicing in Cancer TherapyRNA splicing factors as oncoproteins and tumour suppressors.Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures.Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.Chronic lymphocytic leukemia: Time to go past genomics?Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients.Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.Splicing factor gene mutations in hematologic malignancies.Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.DDX54 regulates transcriptome dynamics during DNA damage responseModeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP.Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors.Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.Antisense transcription-dependent chromatin signature modulates sense transcript dynamics.Insights from structures of cancer-relevant pre-mRNA splicing factors.PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing.Splicing and transcription touch base: co-transcriptional spliceosome assembly and function.Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin.Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency
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P2860
SF3B1 association with chromatin determines splicing outcomes.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
SF3B1 association with chromatin determines splicing outcomes.
@en
type
label
SF3B1 association with chromatin determines splicing outcomes.
@en
prefLabel
SF3B1 association with chromatin determines splicing outcomes.
@en
P2093
P1433
P1476
SF3B1 association with chromatin determines splicing outcomes.
@en
P2093
Adi Alajem
Eran Meshorer
Galit Lev-Maor
Ohad Glaich
P304
P356
10.1016/J.CELREP.2015.03.048
P577
2015-04-16T00:00:00Z