Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats - Wikidata - wikimedia - TriplyDB

Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats

Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats

http://www.wikidata.org/entity/Q41064709

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Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in Obesity Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and The brain is the conductor: diet-induced inflammation overlapping physiological control of body mass and metabolism.High-fat diet induces apoptosis of hypothalamic neurons Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease.Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia.Cardiac, skeletal, and smooth muscle mitochondrial respiration: are all mitochondria created equal?Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.Effect of Hypericum perforatum L. extract on insulin resistance and lipid metabolic disorder in high-fat-diet induced obese mice Central nervous system neuropeptide Y regulates mediators of hepatic phospholipid remodeling and very low-density lipoprotein triglyceride secretion via sympathetic innervation Hypothalamic inflammation: a double-edged sword to nutritional diseases.Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function.Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei Central nervous system neuropeptide Y signaling via the Y1 receptor partially dissociates feeding behavior from lipoprotein metabolism in lean rats.HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons.Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity.Emerging drugs for obesity therapy.Inputs and outputs of insulin receptor.Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor.Hypothalamic dysfunction in obesity.Immortalized neurons for the study of hypothalamic function.Hypothalamic inflammation and thermogenesis: the brown adipose tissue connection.Altered hypothalamic function in diet-induced obesity.PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis.Neuroinflammation and neurodegeneration in overnutrition-induced diseases.Tyrosine kinase inhibitors as novel drugs for the treatment of diabetes.H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria.Crosstalk between insulin and Toll-like receptor signaling pathways in the central nervous system.New molecular targets in the pathophysiology of obesity and available treatment options under investigation.Leptin signalling pathways in hypothalamic neurons.Roux-en-Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats.Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice.Hypothalamic S1P/S1PR1 axis controls energy homeostasis.Modulation of hypothalamic PTP1B in the TNF-alpha-induced insulin and leptin resistance.

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Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats

http://www.wikidata.org/entity/Q41064709

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2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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Juliana Contin Moraes

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Licio Augusto Velloso

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Maria Cristina Cintra Gomes Marcondes

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Mario José Abdalla Saad

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Miriam Ueno

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Patricia Oliveira Prada

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Paty Karoll Picardi

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Vivian Cristine Calegari

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P2860

PTP1B regulates leptin signal transduction in vivo

Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

A central role for JNK in obesity and insulin resistance

Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action.

Hypothalamic K(ATP) channels control hepatic glucose production.

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3870-3880

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10.1210/EN.2007-1506

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8

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149

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José B Carvalheira

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5385125

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18467448

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