Modelling proteins' hidden conformations to predict antibiotic resistance.
about
Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators.Combining experimental and simulation data of molecular processes via augmented Markov models.Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme.Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.Quantifying Allosteric Communication via Both Concerted Structural Changes and Conformational Disorder with CARDS.Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics.Mass Spectrometry-Based Fast Photochemical Oxidation of Proteins (FPOP) for Higher Order Structure Characterization.Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases.Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.Defining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance
P2860
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P2860
Modelling proteins' hidden conformations to predict antibiotic resistance.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Modelling proteins' hidden conformations to predict antibiotic resistance.
@en
type
label
Modelling proteins' hidden conformations to predict antibiotic resistance.
@en
prefLabel
Modelling proteins' hidden conformations to predict antibiotic resistance.
@en
P2093
P2860
P356
P1476
Modelling proteins' hidden conformations to predict antibiotic resistance.
@en
P2093
Chris M W Ho
Gregory R Bowman
Michael L Gross
Supratik Dutta
P2860
P2888
P356
10.1038/NCOMMS12965
P407
P577
2016-10-06T00:00:00Z