Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment
about
Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-Natural Antibodies as Rheostats for Susceptibility to Chronic Diseases in the AgedMost peripheral B cells in mice are ligand selected.Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generationGerm line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies.Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypesDevelopmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3aHuman B-1 cells take the stage.Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptorsContinuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cellsHeavy chain variable (VH) region diversity generated by VH gene replacement in the progeny of a single precursor cell transformed with a temperature-sensitive mutant of Abelson murine leukemia virusLack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary responseRestricted immunoglobulin variable region gene usage by normal Ly-1 (CD5+) B cells that recognize phosphatidyl choline.Facultative role of germinal centers and T cells in the somatic diversification of IgVH genesExpansion of B-1a Cells with Germline Heavy Chain Sequence in Lupus Mice.Differential development of progenitor activity for three B-cell lineages.Tumorigenesis mediated by an antigen receptor.Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells.Adult BM generates CD5+ B1 cells containing abundant N-region additions.Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression.Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral Blood.B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion.Perspectives on fetal derived CD5+ B1 B cellsMolecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.Defining Natural Antibodies.B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures.Abnormalities in the regulation of variable region genes that encode for antibodies to DNA may be a central factor in the pathogenesis of systemic lupus erythematosus.Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release.In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset.PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.
P2860
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P2860
Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Germline antibody V regions as ...... owth in the B cell compartment
@en
type
label
Germline antibody V regions as ...... owth in the B cell compartment
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prefLabel
Germline antibody V regions as ...... owth in the B cell compartment
@en
P2093
P2860
P1433
P1476
Germline antibody V regions as ...... owth in the B cell compartment
@en
P2093
P2860
P304
P407
P577
1988-12-01T00:00:00Z