Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.
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The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helixTumor Suppressor Inactivation in the Pathogenesis of Adult T-Cell Leukemiap53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformationHTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes.Combination of 9-aminoacridine with Campath-1H provides effective therapy for a murine model of adult T-cell leukemiaHuman T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain.Differences in the ability of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53 function.Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53.Evidence for NF-kappaB- and CBP-independent repression of p53's transcriptional activity by human T-cell leukemia virus type 1 Tax in mouse embryo and primary human fibroblasts.Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virusHuman T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.Insight into the tumor suppressor function of CBP through the viral oncoprotein tax.Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax.The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP.Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesisHuman T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1.Human T-cell leukemia virus type 1 tax oncoprotein suppression of multilineage hematopoiesis of CD34+ cells in vitroHuman T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL).Human T cell leukemia virus type-I Tax activates human macrophage inflammatory protein-3 alpha/CCL20 gene transcription via the NF-kappa B pathway.Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax.Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax.A role for mitochondrial Bak in apoptotic response to anticancer drugs.Accelerated G(1) phase progression induced by the human T cell leukemia virus type I (HTLV-I) Tax oncoprotein.Human T-lymphotropic virus type I Tax protein utilizes distinct pathways for p53 inhibition that are cell type-dependent.Suppression of DNA repair by human T cell leukemia virus type 1 Tax is rescued by a functional p53 signaling pathway.HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300.HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration.Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site.Human T-cell leukemia virus type I tax repression of p73beta is mediated through competition for the C/H1 domain of CBP.Utilization of the CBP but not the p300 co-activator by human T-lymphotropic virus type-2 Tax for p53 inhibition.Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein.Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis.
P2860
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P2860
Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.
@en
type
label
Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.
@en
prefLabel
Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.
@en
P2093
P2860
P1433
P1476
Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.
@en
P2093
P2860
P304
P356
10.1016/S0014-5793(97)00280-9
P407
P577
1997-04-01T00:00:00Z