Identification of cytoplasmic subdomains that control pH-sensing of the Na+/H+ exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domains.
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Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangersNa(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophyStructure of Human Na+/H+ Exchanger NHE1 Regulatory Region in Complex with Calmodulin and Ca2+A novel topology model of the human Na(+)/H(+) exchanger isoform 1Quantification of carbonic anhydrase gene expression in ventricle of hypertrophic and failing human heartExpression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchangerNovel phorbol ester-binding motif mediates hormonal activation of Na+/H+ exchanger.Cloning and expression of a chloride-dependent Na+-H+ exchanger.The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border.Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation.Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.Calcineurin homologous protein: a multifunctional Ca2+-binding protein family.Stop Codon Polymorphisms in the Human SLC9A1 Gene Disrupt or Compromise Na+/H+ Exchanger FunctionIntracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.Membrane topology of NHE3. Epitopes within the carboxyl-terminal hydrophilic domain are exoplasmic.SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangersNa+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells.The biophysical and molecular basis of intracellular pH sensing by Na+/H+ exchanger-3Functional importance of charged residues within the putative intracellular loops in pH regulation by Na+/ H+ exchanger NHE1.Mutations of Arg440 and Gly455/Gly456 oppositely change pH sensing of Na+/H+ exchanger 1.Second mutations rescue point mutant of the Na(+)/H(+) exchanger NHE1 showing defective surface expression.Kinetic dissection of two distinct proton binding sites in Na+/H+ exchangers by measurement of reverse mode reaction.Acute pH-dependent regulation of AE2-mediated anion exchange involves discrete local surfaces of the NH2-terminal cytoplasmic domain.Freeze-dried rehydrated human blood platelets regulate intracellular pH.Involvement of the Na+-independent Cl-/HCO3- exchange (AE) isoform in the compensation of myocardial Na+/H+ isoform 1 hyperactivity in spontaneously hypertensive rats.Regulation of AE2 anion exchanger by intracellular pH: critical regions of the NH(2)-terminal cytoplasmic domain.Evidence that Na+/H+ exchanger 1 is an ATP-binding protein.Modulation of Na+/H+ exchange activity by Cl-.
P2860
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P2860
Identification of cytoplasmic subdomains that control pH-sensing of the Na+/H+ exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domains.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Identification of cytoplasmic ...... ve, and flexible loop domains.
@en
type
label
Identification of cytoplasmic ...... ve, and flexible loop domains.
@en
prefLabel
Identification of cytoplasmic ...... ve, and flexible loop domains.
@en
P2093
P1476
Identification of cytoplasmic ...... ve, and flexible loop domains.
@en
P2093
M Shigekawa
S Wakabayashi
P304
P356
10.1093/OXFORDJOURNALS.JBCHEM.A021586
P577
1997-02-01T00:00:00Z