Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
about
IAN family critically regulates survival and development of T lymphocytes.T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionA novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cellsVentricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortexDevelopment of all CD4 T lineages requires nuclear factor TOXResponse to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AXNFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificityc-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xLhBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1).Expression of 4-1BB and 4-1BBL in thymocytes during thymus regenerationc-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells.T cells from epicutaneously immunized mice are prone to T cell receptor revisionReceptor selection in B and T lymphocytes.Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines.The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development.T-cell receptor revision: friend or foe?Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection.Modulation of TCRβ surface expression during TCR revision.RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytesStochastic component to development of class I major histocompatibility complex-specific T cellsCutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host disease.Significance of the detection of Epstein-Barr virus DNA in lymph nodes in patients with Hodgkin's disease.Regulating antigen-receptor gene assembly.Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination.Evidence for a single-niche model of positive selection.Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation.Receptor editing: an approach by autoreactive B cells to escape tolerance.Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineageReceptor editing in self-reactive bone marrow B cells.Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytesThe regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liverTwo waves of recombinase gene expression in developing thymocytes.Small cortical thymocytes are subject to positive selection.Differential effects of zeta and eta transgenes on early alpha/beta T cell development.Surface expression of functional T cell receptor chains formed by interlocus recombination on human T lymphocytes.T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch allelesRequirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection
P2860
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P2860
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
@en
type
label
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
@en
prefLabel
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
@en
P2093
P356
P1433
P1476
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
@en
P2093
McCormack WT
Oettinger MA
Thompson CB
P304
P356
10.1126/SCIENCE.1831564
P407
P577
1991-08-01T00:00:00Z