Identification of a transferable sorting domain for the regulated pathway in the prohormone convertase PC2.
about
Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome.Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 proteaseBinding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturationControl of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasisMechanism of the facilitation of PC2 maturation by 7B2: involvement in ProPC2 transport and activation but not foldingMutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1)Family of prohormone convertases in Lymnaea: characterization of two alternatively spliced furin-like transcripts and cell-specific regulation of their expression.Evidence for a granule targeting sequence within platelet factor 4.Toward gene therapy for growth hormone deficiency via salivary gland expression of growth hormone.Neuroregulation of ProTRH biosynthesis and processing.A look at the Caenorhabditis elegans Kex2/Subtilisin-like proprotein convertase family.Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis.Functional genomics in Caenorhabditis elegans: An approach involving comparisons of sequences from related nematodes.Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targetingRole of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.Role of loop structures of neuropsin in the activity of serine protease and regulated secretion.The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1.Structural Requirements for Sorting Pro-Vasopressin to the Regulated Secretory Pathway in a Neuronal Cell LinePC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesityDibasic cleavage site is required for sorting to the regulated secretory pathway for both pro- and neuropeptide Y.A conserved alpha-helix at the amino terminus of prosomatostatin serves as a sorting signal for the regulated secretory pathway.Lefty proteins exhibit unique processing and activate the MAPK pathway.Involvement of the membrane lipid bilayer in sorting prohormone convertase 2 into the regulated secretory pathway.Activation and routing of membrane-tethered prohormone convertases 1 and 2.Structural elements of PC2 required for interaction with its helper protein 7B2.Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylationFurin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartmentsThe integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking.Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2.
P2860
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P2860
Identification of a transferable sorting domain for the regulated pathway in the prohormone convertase PC2.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Identification of a transferab ...... the prohormone convertase PC2.
@en
type
label
Identification of a transferab ...... the prohormone convertase PC2.
@en
prefLabel
Identification of a transferab ...... the prohormone convertase PC2.
@en
P2093
P2860
P356
P1476
Identification of a transferab ...... the prohormone convertase PC2.
@en
P2093
Creemers JW
Van de Loo JW
Van de Ven WJ
P2860
P304
25284-25291
P356
10.1074/JBC.271.41.25284
P407
P577
1996-10-01T00:00:00Z