about
Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletionRole of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibitionPhenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis.Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis.Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists.Development of 1,8-naphthalimides as clathrin inhibitors.Auto-inhibition of Ca(2+)/calmodulin-dependent protein kinase II by its ATP-binding domain.Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins.Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis.The pthaladyns: GTP competitive inhibitors of dynamin I and II GTPase derived from virtual screening.The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity.Corticotropin releasing hormone: therapeutic implications and medicinal chemistry developments.Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity.Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells.Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening.Development of second-generation indole-based dynamin GTPase inhibitors.Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents.Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.Isolation and identification of unique marker compounds from the Tasmanian poppy Papaver somniferum N. Implications for the identification of illicit heroin of Tasmanian origin.Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors.Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathwaySynthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.Development of quinone analogues as dynamin GTPase inhibitors.Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity.Protein phosphatase inhibition: structure based design. Towards new therapeutic agents.A facile hybrid 'flow and batch' access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones.Identification and validation of small molecule modulators of the NusB-NusE interaction.Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain.Small molecule Hedgehog pathway antagonists.Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.The role of the HPA axis in psychiatric disorders and CRF antagonists as potential treatments.Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells.Small molecule inhibitors of protein kinases in cancer- how to overcome resistance.Dynamin 2 is essential for mammalian spermatogenesis.Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.Serine/threonine phosphatases in socioeconomically important parasitic nematodes--prospects as novel drug targets?Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors.The expanding utility of continuous flow hydrogenation.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Adam McCluskey
@ast
Adam McCluskey
@en
Adam McCluskey
@es
type
label
Adam McCluskey
@ast
Adam McCluskey
@en
Adam McCluskey
@es
prefLabel
Adam McCluskey
@ast
Adam McCluskey
@en
Adam McCluskey
@es
P106
P1153
7004402361
P21
P31
P496
0000-0001-7125-863X