Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease
about
Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune diseaseAmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genesThe Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.High frequency targeted mutagenesis using engineered endonucleases and DNA-end processing enzymes.Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.DNA binding induces active site conformational change in the human TREX2 3'-exonucleaseTREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations.The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.A novel single-stranded DNA-specific 3'-5' exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways
P2860
Q27675483-9B79015E-1CD5-4F4F-BE5E-82B210048BA2Q28493255-7B92921E-87C2-40A9-8AF7-ED154B62577CQ33676423-54939AC4-72AF-438E-9586-36CBB9F9303AQ34325057-7829E683-6D88-4D30-B001-653B4BFE10EFQ35213485-59995C50-F6AD-481E-90DF-7E9C435E45EDQ36355967-5298B9A3-10E0-46E9-8A8E-C76699D68C44Q37169783-A0123D2B-A4DE-49F4-A86F-F864E926CEC6Q41826966-7F2F4EB2-5C09-44B0-8B93-5482CFD017CEQ42151409-C7C7131D-C68C-4DB5-AC31-F135B77EA743Q42423547-DF3E9EAE-4377-4A0E-A750-9591FF980900
P2860
Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Cooperative DNA binding and co ...... he TREX2 3' --> 5'-exonuclease
@en
type
label
Cooperative DNA binding and co ...... he TREX2 3' --> 5'-exonuclease
@en
prefLabel
Cooperative DNA binding and co ...... he TREX2 3' --> 5'-exonuclease
@en
P2093
P2860
P356
P1476
Cooperative DNA binding and co ...... he TREX2 3' --> 5'-exonuclease
@en
P2093
Daniel W Cole
Fred W Perrino
Scott Harvey
Thomas Hollis
Udesh de Silva
P2860
P304
21441-21452
P356
10.1074/JBC.M803629200
P407
P577
2008-06-05T00:00:00Z