T-cell-receptor affinity and thymocyte positive selection.
about
T cell recognition of weak ligands: roles of signaling, receptor number, and affinityThemis controls thymocyte selection through regulation of T cell antigen receptor-mediated signalingSelection of functional T cell receptor mutants from a yeast surface-display libraryT cell receptor mimic antibodies for cancer therapyThe multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cellsTo affinity and beyond: harnessing the T cell receptor for cancer immunotherapyIndoctrinating T cells to attack pathogens through homeschoolingT cell antigen recognition at the cell membraneDefining immune engagement thresholds for in vivo control of virus-driven lymphoproliferationTCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeysClass I major histocompatibility complex anchor substitutions alter the conformation of T cell receptor contactsStructural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2DbStructure of a TCR with high affinity for self-antigen reveals basis for escape from negative selectionT Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexT-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex InteractionsDifferential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligandsTwo-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discriminationT-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APCIn vitro evolution of a T cell receptor with high affinity for peptide/MHC.High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.Engineering higher affinity T cell receptors using a T cell display system.Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.A method to trap transient and weak interacting protein complexes for structural studiesUnderstanding the mechanism of action of bacterial superantigens from a decade of research.Mechanisms of central and peripheral T-cell tolerance: lessons from experimental models of multiple sclerosis.Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization.Molecular interactions between extracellular components of the T-cell receptor signaling complex.Perspectives for computer modeling in the study of T cell activationPeptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.Fast on-rates allow short dwell time ligands to activate T cells.Discrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-lifeStructure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II moleculeFine-tuning T cell receptor signaling to control T cell developmentDissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation.Negative selection of thymocytes expressing the D10 TCRTwo mechanisms that account for major histocompatibility complex restriction of T cells.TCR recognition of peptide/MHC class II complexes and superantigensRegulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X.Cross-reactivity in T-cell antigen recognition.Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers
P2860
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P2860
T-cell-receptor affinity and thymocyte positive selection.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
T-cell-receptor affinity and thymocyte positive selection.
@en
type
label
T-cell-receptor affinity and thymocyte positive selection.
@en
prefLabel
T-cell-receptor affinity and thymocyte positive selection.
@en
P2093
P356
P1433
P1476
T-cell-receptor affinity and thymocyte positive selection.
@en
P2093
Gascoigne NR
Jameson SC
Nasholds W
Travers PJ
P2888
P304
P356
10.1038/381616A0
P407
P577
1996-06-01T00:00:00Z
P6179
1048983992