Fast on-rates allow short dwell time ligands to activate T cells. - Wikidata - wikimedia - TriplyDB

Fast on-rates allow short dwell time ligands to activate T cells.

Fast on-rates allow short dwell time ligands to activate T cells.

http://www.wikidata.org/entity/Q33928549

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An induced rebinding model of antigen discrimination Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse TCR Signaling in T Cell Memory Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens Experimental and theoretical bases for mechanisms of antigen discrimination by T cells Effective T helper cell responses against retroviruses: are all clonotypes equal?A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand Specificity Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.Considerations for combined immune checkpoint modulation and radiation treatment.How the immune system talks to itself: the varied role of synapses Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection.The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness.TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines.Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity.Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection.Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism.Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.MHC class I-associated peptides derive from selective regions of the human genome.Theories and quantification of thymic selection.Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells.Insights into the initiation of TCR signaling.2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.What counts in the immunological synapse?Antigen-driven T-cell repertoire selection during adaptive immune responses.Kinetic proofreading and the search for nonself-peptides.Structural and biophysical determinants of αβ T-cell antigen recognition.Non-catalytic tyrosine-phosphorylated receptors.TCR signal quantity and quality in CD4(+) T cell differentiation.

P2860

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P2860

Fast on-rates allow short dwell time ligands to activate T cells.

http://www.wikidata.org/entity/Q33928549

description

2010 nî lūn-bûn

@nan

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Fast on-rates allow short dwell time ligands to activate T cells.

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Fast on-rates allow short dwell time ligands to activate T cells.

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type

label

Fast on-rates allow short dwell time ligands to activate T cells.

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Fast on-rates allow short dwell time ligands to activate T cells.

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Fast on-rates allow short dwell time ligands to activate T cells.

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Fast on-rates allow short dwell time ligands to activate T cells.

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PNAS.1000966107

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Fast on-rates allow short dwell time ligands to activate T cells.

@en

P2093

Arup K Chakraborty

http://www.w3.org/2001/XMLSchema#string

Christopher C Govern

http://www.w3.org/2001/XMLSchema#string

Eric S Huseby

http://www.w3.org/2001/XMLSchema#string

Michelle K Paczosa

http://www.w3.org/2001/XMLSchema#string

P2860

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

Alternate interactions define the binding of peptides to the MHC molecule IA(b).

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

The immunological synapse: a molecular machine controlling T cell activation

Models for the specific adhesion of cells to cells

A role for rebinding in rapid and reliable T cell responses to antigen

The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes.

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation.

Kinetic proofreading in T-cell receptor signal transduction.

P304

8724-8729

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scholarly article

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10.1073/PNAS.1000966107

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19

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107

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2010-04-26T00:00:00Z

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43345678

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20421471

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2889346

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