Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase.
about
Multiple roles of TNF super family members in corpus luteum functionSphingolipid signaling in metabolic disordersOn ceramides, other sphingolipids and impaired glucose homeostasisFat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysisInsulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathwaysSrc homology 3 domain-dependent interaction of Nck-2 with insulin receptor substrate-1Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsA molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphoryRegulation of mucin MUC2 gene expression during colon carcinogenesis.Impact of resistant starch on body fat patterning and central appetite regulation.Rodent mutant models of obesity and their correlations to human obesity.Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.Upregulation of Tumor Necrosis Factor-α-Induced Protein 8-Like 2 mRNA Is Negatively Correlated with Serum Concentrations of Tumor Necrosis Factor-α and Interleukin 6 in Type 2 Diabetes MellitusTumor necrosis factor-alpha-induced insulin resistance in adipocytes.Signaling pathways mediating insulin-stimulated glucose transport.Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscleGenome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation.Mechanisms of insulin resistance in obesityDe Novo Lipogenesis Products and Endogenous Lipokines.Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patientsEffect of early particulate air pollution exposure on obesity in mice: role of p47phoxTNF-alpha and adipocyte biology.The role of intramuscular lipid in insulin resistance.The inflammatory changes of adipose tissue in late pregnant mice.A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.Transplantation of Human Neural Progenitor Cells Expressing IGF-1 Enhances Retinal Ganglion Cell Survival.Relationships between serum adiponectin and soluble TNF-α receptors and glucose and lipid oxidation in lean and obese subjects.Adipose tissue stem cells meet preadipocyte commitment: going back to the future.Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and β-cellsThe brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance.Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance.Insulin-sensitising agents: beyond thiazolidinediones.Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner.Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases.4-Hydroxyisoleucine improves insulin resistance in HepG2 cells by decreasing TNF-α and regulating the expression of insulin signal transduction proteins.Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactationProtective Effect of Vanillic Acid against Hyperinsulinemia, Hyperglycemia and Hyperlipidemia via Alleviating Hepatic Insulin Resistance and Inflammation in High-Fat Diet (HFD)-Fed Rats
P2860
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P2860
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Tumor necrosis factor (TNF)-al ...... ctivation of sphingomyelinase.
@en
type
label
Tumor necrosis factor (TNF)-al ...... ctivation of sphingomyelinase.
@en
prefLabel
Tumor necrosis factor (TNF)-al ...... ctivation of sphingomyelinase.
@en
P2093
P356
P1476
Tumor necrosis factor (TNF)-al ...... ctivation of sphingomyelinase.
@en
P2093
Buurman WA
Hotamisligil GS
Spiegelman BM
P304
13018-13022
P356
10.1074/JBC.271.22.13018
P407
P577
1996-05-01T00:00:00Z