A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
about
Hepatic steatosis: a benign disease or a silent killerModulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta53BP2S, interacting with insulin receptor substrates, modulates insulin signalingThe crosstalk of mTOR/S6K1 and Hedgehog pathwaysS6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationmTOR inhibitors in advanced renal cell carcinomaThe mTOR signalling pathway in human cancerMolecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunctionBalancing Akt with S6K: implications for both metabolic diseases and tumorigenesisAcetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylationThe Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and MetabolismObesity and cancer, a case for insulin signalingInsulin receptor signaling in normal and insulin-resistant statesGammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic diseaseInvolvement of the PA28 -Dependent Pathway in Insulin Resistance Induced by Hepatitis C Virus Core ProteinSTEATOSIS IN CHRONIC HEPATITIS C: WHY DOES IT REALLY MATTER?Molecular mechanisms of insulin resistance in chronic hepatitis CHyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytesAdipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activityInvolvement of mTOR in Type 2 CRF Receptor Inhibition of Insulin Signaling in Muscle Cells.Insulin resistance without elevated mammalian target of rapamycin complex 1 activity in muscles of mice fed a high-fat diet.Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells.Interactions between PTEN and receptor tyrosine kinase pathways and their implications for glioma therapyActivation of SOCS-3 by resistinA dynamic analysis of IRS-PKR signaling in liver cells: a discrete modeling approach.Data Mining of Determinants of Intrauterine Growth Retardation Revisited Using Novel Algorithms Generating Semantic Maps and Prototypical Discriminating Variable ProfilesPhosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to inEffect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistanceDissecting the mechanism of insulin resistance using a novel heterodimerization strategy to activate Akt.Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.Prostaglandin F2alpha represses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase.Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.Information theoretic approach to complex biological network reconstruction: application to cytokine release in RAW 264.7 macrophagesChronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes.The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cellsDistinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice.mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
P2860
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P2860
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A phosphatidylinositol 3-kinas ...... insulin receptor substrate-1.
@ast
A phosphatidylinositol 3-kinas ...... insulin receptor substrate-1.
@en
type
label
A phosphatidylinositol 3-kinas ...... insulin receptor substrate-1.
@ast
A phosphatidylinositol 3-kinas ...... insulin receptor substrate-1.
@en
prefLabel
A phosphatidylinositol 3-kinas ...... insulin receptor substrate-1.
@ast
A phosphatidylinositol 3-kinas ...... insulin receptor substrate-1.
@en
P2093
P2860
P356
P1476
A phosphatidylinositol 3-kinas ...... insulin receptor substrate-1.
@en
P2093
D B Donner
J A Gustin
P2860
P304
P356
10.1073/PNAS.051042298
P407
P577
2001-04-03T00:00:00Z