Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK.
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Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/TxkEvidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signalingThe influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activationGrowth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signalingHuman homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytesPositive and negative regulation of T-cell activation through kinases and phosphatasesThe proline rich region of the Tec homology domain of ITK regulates its activityLck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activityGrb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interactionThe role of Tec protein-tyrosine kinase in T cell signalingPhosphorylation site dynamics of early T-cell receptor signalingFyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cellsThe Tec family kinase Itk exists as a folded monomer in vivo.A weak Lck tail bite is necessary for Lck function in T cell antigen receptor signaling.Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.Removal of C-terminal SRC kinase from the immune synapse by a new binding proteinFunctional analysis of the T-cell-restricted protein tyrosine kinase Txk.Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.T-cell receptor complex is essential for Fas signal transduction.People's instinctive travels and the paths to science.Itk: the rheostat of the T cell response.A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selectionAntiviral immune responses in Itk-deficient mice.Itk negatively regulates induction of T cell proliferation by CD28 costimulation.T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cellsSignal transduction via the T cell antigen receptor in naïve and effector/memory T cells.Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinaseRegulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.ITK inhibitors in inflammation and immune-mediated disorders.CD28: a signalling perspective.PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors.Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK.IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-IEvidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28.A switch in nucleotide affinity governs activation of the Src and Tec family kinases.
P2860
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P2860
Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Functional LCK Is required for ...... amily tyrosine kinase EMT/ITK.
@en
type
label
Functional LCK Is required for ...... amily tyrosine kinase EMT/ITK.
@en
prefLabel
Functional LCK Is required for ...... amily tyrosine kinase EMT/ITK.
@en
P2093
P2860
P356
P1476
Functional LCK Is required for ...... amily tyrosine kinase EMT/ITK.
@en
P2093
P2860
P304
P356
10.1074/JBC.271.12.7079
P407
P577
1996-03-01T00:00:00Z