Identification of a major protein kinase C-binding protein and substrate in rat embryo fibroblasts. Decreased expression in transformed cells.
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Cross-species sequence analysis reveals multiple charged residue-rich domains that regulate nuclear/cytoplasmic partitioning and membrane localization of a kinase anchoring protein 12 (SSeCKS/Gravin)A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvationCharacterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase CSpecific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alphaSSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway.Gene expression profiling of fibroblasts resistant toward oncogene-mediated transformation reveals preferential transcription of negative growth regulators.Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles.Protein kinase C binding partners.Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters.Protein kinase C modulation and anticancer drug response.Emerging Roles for SSeCKS/Gravin/AKAP12 in the Control of Cell Proliferation, Cancer Malignancy, and Barriergenesis.Control of protein kinase C activity, phorbol ester-induced cytoskeletal remodeling, and cell survival signals by the scaffolding protein SSeCKS/GRAVIN/AKAP12.Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics: Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling.AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repairLocalization of SSeCKS in unmyelinated primary sensory neuronsSuppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)-->S progression by controlling the expression and cellular compartmentalization of cyclin D.Induction of Src-suppressed C kinase substrate (SSeCKS) in vascular endothelial cells by bacterial lipopolysaccharide.A major, transformation-sensitive PKC-binding protein is also a PKC substrate involved in cytoskeletal remodeling.A novel src- and ras-suppressed protein kinase C substrate associated with cytoskeletal architecture.Protein kinase A anchoring.Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12.Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction.Adhesion of epithelial cells to fibronectin or collagen I induces alterations in gene expression via a protein kinase C-dependent mechanism.Molecular characterization of protein kinase C-alpha binding to lamin A.Developmental expression of the protein kinase C substrate/binding protein (clone 72/SSeCKS) in rat testis identification as a scaffolding protein containing an A-kinase-anchoring domain which is expressed during late-stage spermatogenesis.Expression of SRC suppressed C kinase substrate in rat neural tissues during inflammation.The relationship between Src-suppressed C kinase substrate and β-1,4 galactosyltransferase-I in the process of lipopolysaccharide-induced TNF-α secretion in rat primary astrocytes.Identification of the linker histone H1 as a protein kinase Cε-binding protein in vascular smooth muscle
P2860
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P2860
Identification of a major protein kinase C-binding protein and substrate in rat embryo fibroblasts. Decreased expression in transformed cells.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Identification of a major prot ...... pression in transformed cells.
@en
type
label
Identification of a major prot ...... pression in transformed cells.
@en
prefLabel
Identification of a major prot ...... pression in transformed cells.
@en
P2093
P2860
P356
P1476
Identification of a major prot ...... pression in transformed cells.
@en
P2093
Chapline C
Mousseau B
P2860
P304
P356
10.1074/JBC.271.11.6417
P407
P577
1996-03-01T00:00:00Z