Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12.
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NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressorIn vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells.Rapamycin induces pluripotent genes associated with avoidance of replicative senescenceSuppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge.Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epitheliumControl of protein kinase C activity, phorbol ester-induced cytoskeletal remodeling, and cell survival signals by the scaffolding protein SSeCKS/GRAVIN/AKAP12.Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.Molecular damage in cancer: an argument for mTOR-driven agingPivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics: Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling.AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repairA mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells.Mutant lamin A links prophase to a p53 independent senescence program.Repeated intra-nigrostriatal injection of phorbol myristate acetate induces microglial senescence in adult rats.Whole Chromosome Instability induces senescence and promotes SASP.Suppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12Mapping genetic alterations causing chemoresistance in cancer: identifying the roads by tracking the drivers.Protein kinase C and cancer: what we know and what we do not.Tuning the signalling output of protein kinase C.Scaffolding during the cell cycle by A-kinase anchoring proteins.Inflammation induces multinucleation of Microglia via PKC inhibition of cytokinesis, generating highly phagocytic multinucleated giant cells.MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells.Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma.MicroRNAs as molecular classifiers for cancer.A transgenic mouse model for early prostate metastasis to lymph nodes.Adhesion-mediated cytoskeletal remodeling is controlled by the direct scaffolding of Src from FAK complexes to lipid rafts by SSeCKS/AKAP12.SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts.Role of A-Kinase Anchoring Protein Phosphorylation in Alcohol-Induced Liver Injury and Hepatic Stellate Cell Activation.Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression.SSeCKS sequesters cyclin D1 in glomerular parietal epithelial cells and influences proliferative injury in the glomerulus.2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes astrocyte activation and the secretion of tumor necrosis factor-α via PKC/SSeCKS-dependent mechanisms.SSeCKS/Akap12 suppresses metastatic melanoma lung colonization by attenuating Src-mediated pre-metastatic niche crosstalk
P2860
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P2860
Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Rb-dependent cellular senescen ...... scaffolding by SSeCKS/AKAP12.
@en
type
label
Rb-dependent cellular senescen ...... scaffolding by SSeCKS/AKAP12.
@en
prefLabel
Rb-dependent cellular senescen ...... scaffolding by SSeCKS/AKAP12.
@en
P2093
P2860
P356
P1433
P1476
Rb-dependent cellular senescen ...... scaffolding by SSeCKS/AKAP12.
@en
P2093
Irwin H Gelman
Lingqiu Gao
Paula Sotomayor
Peter Nochajski
Sei-ichi Matsui
Shin Akakura
P2860
P304
P356
10.4161/CC.9.23.13974
P577
2010-12-01T00:00:00Z