Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.
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The paracaspase MALT1: biological function and potential for therapeutic inhibitionTCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complexThe paracaspase MALT1 mediates CARD14-induced signaling in keratinocytesAlternative splicing of MALT1 controls signalling and activation of CD4(+) T cellsThe paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.The Paracaspase MALT1.CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation.A role for MALT1 activity in Kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma.MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression.Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation.The identification of up-regulated ebv-miR-BHRF1-2-5p targeting MALT1 and ebv-miR-BHRF1-3 in the circulation of patients with multiple sclerosis.MALT1 is an intrinsic regulator of regulatory T cells.Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation.MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling.The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-κB signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells.The CBM-opathies-A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex
P2860
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P2860
Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.
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2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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name
Deficiency of MALT1 paracaspas ...... ng to multiorgan inflammation.
@en
type
label
Deficiency of MALT1 paracaspas ...... ng to multiorgan inflammation.
@en
prefLabel
Deficiency of MALT1 paracaspas ...... ng to multiorgan inflammation.
@en
P2093
P50
P356
P1476
Deficiency of MALT1 paracaspas ...... ng to multiorgan inflammation.
@en
P2093
Andreas Katopodis
Anne Brüstle
Antonius Rolink
Barbara Nuesslein-Hildesheim
Bernd Kinzel
Christoph Burkhart
Dhavalkumar D Patel
Elisabetta Traggiai
Florian Renner
Frédéric Bornancin
P304
P356
10.4049/JIMMUNOL.1402254
P407
P577
2015-03-11T00:00:00Z