High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas. - Wikidata - wikimedia - TriplyDB

High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

http://www.wikidata.org/entity/Q41287827

about

p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system MDM2 and MDMX: Alone and together in regulation of p53 High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia.Mouse models of p53 functions.Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4 A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer.Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability Prognostic impact of the MDM2SNP309 allele in leukemia and lymphoma.Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx XI-006 induces potent p53-independent apoptosis in Ewing sarcoma.Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia Ligand binding mode prediction by docking: mdm2/mdmx inhibitors as a case study The Role of p53 and MDM2 in Head and Neck Cancer.Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?Molecular techniques and genetic alterations in head and neck cancer.The role of p53 in pigmentation, tanning and melanoma.A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors.The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer.The associations between MDM4 gene polymorphisms and cancer risk Functions of MDMX in the modulation of the p53-response.Molecular and cellular processes underlying the hallmarks of head and neck cancer.Mouse models of Mdm2 and Mdm4 and their clinical implications.Implications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. Part I: targeting p53, Mdm2, GADD153/CHOP, GRP78/BiP and heat shock proteins.The Mdm network and its regulation of p53 activities: a rheostat of cancer risk.XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer.A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival.MDM2 promoter SNP309 is associated with an increased susceptibility to chronic lymphocytic leukemia and correlates with MDM2 mRNA expression in Chinese patients with CLL.p53 pathway dysfunction in AML: beyond TP53 mutations.MDM4 genetic variants predict HPV16-positive tumors of patients with squamous cell carcinoma of the oropharynx.The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.BRCA1 and MDM2 as independent blood-based biomarkers of head and neck cancer.MDMX is a prognostic factor for non-small cell lung cancer and regulates its sensitivity to cisplatin.Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.The Roles of MDM2 and MDMX in Cancer.In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas.

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P2860

High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

http://www.wikidata.org/entity/Q41287827

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

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type

label

High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

@en

prefLabel

High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

@en

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J.HUMPATH.2007.03.005

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Human Pathology

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High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

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Adel K El-Naggar

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Gilda P Chau

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Guillermina Lozano

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Juan A Barboza

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Yasmine A Valentin-Vega

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P2860

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

MDMX: a novel p53-binding protein with some functional properties of MDM2

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Regulation of p53 stability by Mdm2

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

Amplification of a gene encoding a p53-associated protein in human sarcomas

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2699677

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