Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking.
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The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteinsThe p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complexSubsets of epidermal growth factor receptors during activation and endocytosisRegulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through AktRecruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2Human VPS34 is required for internal vesicle formation within multivesicular endosomesPhosphoinositides in the mammalian endo-lysosomal networkOsmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinaseMig-6 is a negative regulator of the epidermal growth factor receptor signalCTLA-4 trafficking and surface expressionWortmannin-sensitive trafficking steps in the endocytic pathway in rat liver endothelial cellsExpression cloning of protein targets for 3-phosphorylated phosphoinositidesRegulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunitPDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylationVp165 and GLUT4 share similar vesicle pools along their trafficking pathways in rat adipose cellsRegulation of AP-3 function by inositides. Identification of phosphatidylinositol 3,4,5-trisphosphate as a potent ligandA role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophagesc-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptorRequirement for the adapter protein GRB2 in EGF receptor endocytosis.Regulation of endosome fusion.Fc receptor signaling and trafficking: a connection for antigen processing.Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathwayDileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site.Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs.The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation.Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brainRhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells.Inhibitors of phosphoinositide 3-kinase cause defects in the postendocytic sorting of beta2-adrenergic receptors.The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha.Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartmentDistinct roles for the p110alpha and hVPS34 phosphatidylinositol 3'-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis.Evidence for apical endocytosis in polarized hepatic cells: phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteinsPhosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits.Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmanninSpecific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways.Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.Regulation of the epithelial sodium channel by membrane trafficking.Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.
P2860
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P2860
Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Phosphatidylinositol 3-kinase ...... h factor receptor trafficking.
@en
type
label
Phosphatidylinositol 3-kinase ...... h factor receptor trafficking.
@en
prefLabel
Phosphatidylinositol 3-kinase ...... h factor receptor trafficking.
@en
P2093
P2860
P356
P1476
Phosphatidylinositol 3-kinase ...... h factor receptor trafficking.
@en
P2093
P2860
P304
13225-13230
P356
10.1074/JBC.270.22.13225
P407
P577
1995-06-01T00:00:00Z