Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations.
about
Neuropeptide Y Y2 receptor in health and diseaseAutomated solid-phase peptide synthesis to obtain therapeutic peptidesThe SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptorBiophysical methods to study ligand-receptor interactions of neuropeptide YA pool of Y2 neuropeptide Y receptors activated by modifiers of membrane sulfhydryl or cholesterol balanceBODIPY-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypesFrom consensus sequence peptide to high affinity ligand, a "library scan" strategy.A Y2 receptor mimetic aptamer directed against neuropeptide Y.The role of NPY in metabolic homeostasis: implications for obesity therapy.Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail.Non-specific binding and general cross-reactivity of Y receptor agonists are correlated and should importantly depend on their acidic sectors.A parallel semisynthetic approach for structure-activity relationship studies of peptide YY.The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanismNovel dimeric DOTA-coupled peptidic Y1-receptor antagonists for targeting of neuropeptide Y receptor-expressing cancers.The Arginine Residue within the C-Terminal Active Core of Bombyx mori Pheromone Biosynthesis-Activating Neuropeptide is Essential for Receptor Binding and ActivationThe anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivoAre hormones from the neuropeptide Y family recognized by their receptors from the membrane-bound state?Recognition of neurohormones of the NPY family by their receptors.Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.Anticonvulsant neuropeptides as drug leads for neurological diseases.Neuropeptide Y receptors: ligand binding and trafficking suggest novel approaches in drug development.Neuropeptide Y receptors: how to get subtype selectivityNPY binds with heme to form a NPY-heme complex: enhancing peroxidase activity in free heme and promoting NPY nitration and inactivation.Progress with peptide scanning to study structure-activity relationships: the implications for drug discovery.Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypesDesign and Synthesis of Peptide YY Analogues with C-terminal Backbone Amide-to-Ester Modifications.A simple and powerful flow cytometric method for the simultaneous determination of multiple parameters at G protein-coupled receptor subtypes.Novel cell line selectively expressing neuropeptide Y-Y2 receptors.Novel analogues of neuropeptide Y with a preference for the Y1-receptor.In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans.Primary structures of PYY, [Pro(34)]PYY, and PYY-(3-36) confer different conformations and receptor selectivity.Structure activity studies of mast cell activation and hypotension induced by neuropeptide Y (NPY), centrally truncated and C-terminal NPY analogues.The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.A Blocking Group Scan Using a Spherical Organometallic Complex Identifies an Unprecedented Binding Mode with Potent Activity In Vitro and In Vivo for the Opioid Peptide Dermorphin.Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptors.Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles.Receptor subtype-specific docking of Asp6.59 with C-terminal arginine residues in Y receptor ligands.Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y2receptorA Chimeric GPCR Model Mimicking the Ligand Binding Site of the Human Y1 Receptor Studied by NMR Spectroscopy
P2860
Q24648453-BA021389-3C3F-4186-99B1-6FEB30FE2C10Q27001623-98422E27-3D27-453D-8C36-CBF720F92BEDQ28202595-C5173D61-18BC-4350-B12A-8015FEF4C6C2Q28220437-336FF4FF-BFDC-448C-A97E-113E1BBEEB0DQ28580590-CB81C4D1-A2CB-44A5-ABDF-B96FDFA62CD0Q28583085-76C5640F-0B37-4ECC-A2C2-7829D928A12DQ30661674-8AB4201F-7F01-4EFB-AE9E-3209F28E126CQ31033093-2869B567-12E2-4448-8725-19B52A08DC2FQ34074911-872CDE0D-748A-4B8E-A2FB-F1BFBC4A9034Q34438861-455DB5CF-3E47-4BA4-BAE4-DB093BCD287BQ34511139-732ADB8A-6CD9-467E-9CEF-92236FB2F5CAQ34888703-EF9C3DA5-1D28-4570-B0BA-D62E9912E65CQ35159111-8CE03A2E-2B1F-42CF-87D4-9D63893D2518Q35650466-6DD43B60-C148-471C-992B-17DD81D4DD90Q35972051-679013F0-C64D-4819-B318-D34067D75D72Q36004364-D30B465E-DDDD-4BA2-879F-B71DE2B0FB53Q36204247-2E5C0F0E-2221-441E-825B-7944CD57BAF3Q36659833-D1181437-DF6A-4781-925B-37FA56295B45Q37608494-42EE7E70-6A13-4D4B-A7D2-E74869A3E23BQ37845684-79AC2FCC-4A90-4F2A-94FD-6E21F5103F6FQ37847125-533A1B8E-0C31-4F94-AAC4-F5D055FAA9E7Q38079230-CD5D4CA3-F5DD-4103-8286-263F9884846BQ38665001-2569D571-7218-46FB-9A4D-9814131F9DD2Q38867099-7B16D799-C6A6-430A-957D-F6C459692327Q39009770-AFEB7E93-9B36-4804-98D7-17C5F66BED1CQ39775436-864683C1-3DCF-4582-A19B-DE325375D7ABQ40247599-33EC2CF0-F904-44BA-8202-4BEDB461FEFBQ40593925-8B184615-76B3-4A87-A914-D950EECCF5D3Q40805267-6C74CF1F-A58F-414E-A85E-199BF5436D63Q40953070-290EA13B-0D2C-4726-8370-A686177353ACQ41747980-48A74FF3-4EA3-4E52-B44C-535AC232CE9AQ42090889-F5A14859-7B10-4D82-B92F-0DA9CF70A35EQ42442169-25FE5526-21DB-4E5E-BA1F-99A018F5EB8EQ44339606-CAEA48F6-BF85-4E96-96B6-7F99609BFBE7Q48192978-C06EAE0A-7AAD-43BB-870F-4B5CBE4984B1Q49507908-5DEA1C24-7AB8-42B2-989F-AAA080C6AD67Q51800848-712A444B-0FB7-4398-BB0A-77A23348ADBCQ56426242-95B5C499-4973-4050-B60B-3EBAB81ED0BFQ57794644-15C68856-EA20-4300-9480-E4052803AD99
P2860
Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Complete L-alanine scan of neu ...... h distinguished conformations.
@en
type
label
Complete L-alanine scan of neu ...... h distinguished conformations.
@en
prefLabel
Complete L-alanine scan of neu ...... h distinguished conformations.
@en
P2093
P2860
P1433
P1476
Complete L-alanine scan of neu ...... h distinguished conformations.
@en
P2093
A G Beck-Sickinger
H A Wieland
H Wittneben
K D Willim
P2860
P304
P356
10.1111/J.1432-1033.1994.0947B.X
P407
P577
1994-11-01T00:00:00Z