Loss of RCC1 leads to suppression of nuclear protein import in living cells.
about
The mechanism of nuclear export of Smad3 involves exportin 4 and Ranp619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteinsInhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase RanIdentification of different roles for RanGDP and RanGTP in nuclear protein importSeparate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processingNuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanismsAltered RNA processing and export lead to retention of mRNAs near transcription sites and nuclear pore complexes or within the nucleolus.Mutants in a yeast Ran binding protein are defective in nuclear transport.Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein.Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear importRna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import.A novel nuclear pore protein Nup82p which specifically binds to a fraction of Nsp1p.beta-catenin can be transported into the nucleus in a Ran-unassisted mannerDisruption of the ran system by cysteine oxidation of the nucleotide exchange factor RCC1The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTPA cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells.Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos.TD-60 is required for interphase cell cycle progressionFunctional domains in nuclear import factor p97 for binding the nuclear localization sequence receptor and the nuclear poreRCC1 and nuclear organization.A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea.Discovery of parasite virulence genes reveals a unique regulator of chromosome condensation 1 ortholog critical for efficient nuclear trafficking.Nucleocytoplasmic recycling of the nuclear localization signal receptor alpha subunit in vivo is dependent on a nuclear export signal, energy, and RCC1Subnuclear trafficking of glucocorticoid receptors in vitro: chromatin recycling and nuclear exportCellular stresses induce the nuclear accumulation of importin alpha and cause a conventional nuclear import block.Nucleocytoplasmic transport of macromoleculesGTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein importA T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein importNuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene.A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cellsMolecular Signatures of Recurrent Hepatocellular Carcinoma Secondary to Hepatitis C Virus following Liver Transplantation.In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe.In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import.Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificitiesRAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.
P2860
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P2860
Loss of RCC1 leads to suppression of nuclear protein import in living cells.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Loss of RCC1 leads to suppression of nuclear protein import in living cells.
@en
type
label
Loss of RCC1 leads to suppression of nuclear protein import in living cells.
@en
prefLabel
Loss of RCC1 leads to suppression of nuclear protein import in living cells.
@en
P2093
P1476
Loss of RCC1 leads to suppression of nuclear protein import in living cells.
@en
P2093
P304
24542-24545
P407
P577
1994-10-01T00:00:00Z