Convergent evolution of enzyme active sites is not a rare phenomenon.
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On universal common ancestry, sequence similarity, and phylogenetic structure: the sins of P-values and the virtues of Bayesian evidenceIdentical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrateStructural Basis of Substrate Conversion in a New Aromatic Peroxygenase: CYTOCHROME P450 FUNCTIONALITY WITH BENEFITSThe Classification and Evolution of Enzyme FunctionQuantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes: implications for classification of enzyme functionEvolution of bacterial phosphoglycerate mutases: non-homologous isofunctional enzymes undergoing gene losses, gains and lateral transfersAn Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based CofactorsEvolutionary diversification and characterization of the eubacterial gene family encoding DXR type II, an alternative isoprenoid biosynthetic enzymeEvolution: like any other science it is predictableFunClust: a web server for the identification of structural motifs in a set of non-homologous protein structuresProtein change in plant evolution: tracing one thread connecting molecular and phenotypic diversityDetecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments.The enzymatic nature of an anonymous protein sequence cannot reliably be inferred from superfamily level structural information aloneDiscrete-continuous duality of protein structure space.Modular architecture of nucleotide-binding pockets.Discriminative structural approaches for enzyme active-site prediction.Resolving protein structure-function-binding site relationships from a binding site similarity network perspective.Structural motifs recurring in different folds recognize the same ligand fragmentsSuperpose3D: a local structural comparison program that allows for user-defined structure representations.ProBiS algorithm for detection of structurally similar protein binding sites by local structural alignment.Isolation of the opdE gene that encodes for a new hydrolase of Enterobacter sp. capable of degrading organophosphorus pesticides.Active site detection by spatial conformity and electrostatic analysis--unravelling a proteolytic function in shrimp alkaline phosphatase.Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies.Metric learning for enzyme active-site search.Identification of ligand templates using local structure alignment for structure-based drug design.Structural phylogeny by profile extraction and multiple superimposition using electrostatic congruence as a discriminator.The evolution of enzyme function in the isomerases.One origin for metallo-β-lactamase activity, or two? An investigation assessing a diverse set of reconstructed ancestral sequences based on a sample of phylogenetic trees.A measure of the broad substrate specificity of enzymes based on 'duplicate' catalytic residuesMultiBind and MAPPIS: webservers for multiple alignment of protein 3D-binding sites and their interactionsA computational module assembled from different protease family motifs identifies PI PLC from Bacillus cereus as a putative prolyl peptidase with a serine protease scaffoldThe dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.An assessment of catalytic residue 3D ensembles for the prediction of enzyme functionSequence/structural analysis of xylem proteome emphasizes pathogenesis-related proteins, chitinases and β-1, 3-glucanases as key players in grapevine defense against Xylella fastidiosa.A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discoveryAn empirical test of convergent evolution in rhodopsins.Auxiliary phosphatases in two-component signal transduction.Toward mechanistic classification of enzyme functions.Enzyme informatics.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.
P2860
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P2860
Convergent evolution of enzyme active sites is not a rare phenomenon.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Convergent evolution of enzyme active sites is not a rare phenomenon.
@en
type
label
Convergent evolution of enzyme active sites is not a rare phenomenon.
@en
prefLabel
Convergent evolution of enzyme active sites is not a rare phenomenon.
@en
P50
P1476
Convergent evolution of enzyme active sites is not a rare phenomenon.
@en
P2093
Michael J E Sternberg
P304
P356
10.1016/J.JMB.2007.06.017
P407
P577
2007-06-14T00:00:00Z