The structure, function and application of the hammerhead ribozyme.
about
Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replicationMethodological obstacles in knocking down small noncoding RNAsDown-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytesUnrooted unordered homeomorphic subtree alignment of RNA treesInhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose productionRecent advances in the elucidation of the mechanisms of action of ribozymesHIV-1 LTR as a target for synthetic ribozyme-mediated inhibition of gene expression: site selection and inhibition in cell cultureCleavage of highly structured viral RNA molecules by combinatorial libraries of hairpin ribozymes. The most effective ribozymes are not predicted by substrate selection rules.Selection, design, and characterization of a new potentially therapeutic ribozyme.Computational RNA secondary structure design: empirical complexity and improved methods.A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme.Saccharide-RNA recognition.Ribozymes: the characteristics and properties of catalytic RNAs.Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition SystemsCapped antigenomic RNA transcript facilitates rescue of a plant rhabdovirusNonreplicative RNA recombination in poliovirusFunctional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity.Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3' end can be exported efficiently and specifically to the cytoplasm in mammalian cellsThe fission yeast RNA binding protein Mmi1 regulates meiotic genes by controlling intron specific splicing and polyadenylation coupled RNA turnover.Intracellular ribozyme-catalyzed trans-cleavage of RNA monitored by fluorescence resonance energy transfer.Replacement of the yeast TRP4 3' untranslated region by a hammerhead ribozyme results in a stable and efficiently exported mRNA that lacks a poly(A) tail.RNase P: variations and uses.Synthetic hammerhead ribozymes as tools in gene expression.Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNAEffects of helical structures formed by the binding arms of DNAzymes and their substrates on catalytic activityDistribution of hammerhead and hammerhead-like RNA motifs through the GenBank.Variables and strategies in development of therapeutic post-transcriptional gene silencing agentsRibozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy.A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate.RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNAIn vitro selection of a purine nucleotide-specific hammerheadlike ribozyme.Characterization of Three Mycobacterium spp. with Potential Use in Bioremediation by Genome Sequencing and Comparative Genomics.A modular and extensible RNA-based gene-regulatory platform for engineering cellular functionSequence-specific RNA Photocleavage by Single-stranded DNA in Presence of Riboflavin.Potential therapy paradigms for Marfan syndrome.A small nucleolar RNA:ribozyme hybrid cleaves a nucleolar RNA target in vivo with near-perfect efficiencyBridging the gap between theory and experiment to derive a detailed understanding of hammerhead ribozyme catalysis.Down-regulation of Fas-L in glioma cells by ribozyme reduces cell apoptosis, tumour-infiltrating cells, and liver damage but accelerates tumour formation in nude mice.Hyperstable U1snRNA complementary to the K-ras transcripts induces cell death in pancreatic cancer cells.RNA as a versatile and powerful platform for engineering genetic regulatory tools.
P2860
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P2860
The structure, function and application of the hammerhead ribozyme.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The structure, function and application of the hammerhead ribozyme.
@en
type
label
The structure, function and application of the hammerhead ribozyme.
@en
prefLabel
The structure, function and application of the hammerhead ribozyme.
@en
P2093
P2860
P1433
P1476
The structure, function and application of the hammerhead ribozyme.
@en
P2093
F Eckstein
K R Birikh
P A Heaton
P2860
P356
10.1111/J.1432-1033.1997.T01-3-00001.X
P407
P577
1997-04-01T00:00:00Z