Pharmacokinetics of the natural antibiotic negamycin.

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Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens

P2860

Q35960643-F8A1FD5C-1DDA-4D0B-80F8-36F5743ECD54

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Pharmacokinetics of the natural antibiotic negamycin.

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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name

Pharmacokinetics of the natural antibiotic negamycin.

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type

Item

label

Pharmacokinetics of the natural antibiotic negamycin.

@en

prefLabel

Pharmacokinetics of the natural antibiotic negamycin.

@en

P1476

Pharmacokinetics of the natural antibiotic negamycin.

@en

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April Chen

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Ed T Buurman

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Eric W Miele

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Jian Guo

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Mark Zambrowski

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Ricardo A Luzietti

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Robert L Walsky

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P2860

Analysis of underivatized amino acid mixtures using high performance liquid chromatography/dual oscillating nebulizer atmospheric pressure microwave induced plasma ionization-mass spectrometry.

Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA

Plasma terminal half-life.

Volumes of distribution.

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance.

A fresh look at the mechanism of isoniazid-induced hepatotoxicity.

Lipophilicity in drug discovery.

Use of the Øie-Tozer model in understanding mechanisms and determinants of drug distribution.

Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption.

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625-633

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scholarly article

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10.3109/00498254.2015.1006301

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English

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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2015-03-03T00:00:00Z

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P698

25733027

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P921

antibiotic

Pharmacokinetics of the natural antibiotic negamycin.

about

P2860

P2860

Pharmacokinetics of the natural antibiotic negamycin.

description

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type

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prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P921

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P921