The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone alpha-subunit gene in pituitary gonadotropes.
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Regulation of alpha-fetoprotein expression by Nkx2.8Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroidsSF-1 a key player in the development and differentiation of steroidogenic tissuesNuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta geneNR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo.Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches.Genetic regulation of pituitary gland development in human and mouseMinireview: steroidogenic factor 1: its roles in differentiation, development, and diseasePituitary homeobox 2 regulates adrenal4 binding protein/steroidogenic factor-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancerNuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1Susceptible periods during embryogenesis of the heart and endocrine glandsRole of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal growth factor and forskolin.An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation.Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRHThe expression of the follicle-stimulating hormone receptor in spermatogenesis.Birthdating studies reshape models for pituitary gland cell specificationA FTZ-F1-containing yeast artificial chromosome recapitulates expression of steroidogenic factor 1 in vivo.Expression of steroidogenic factor 1 in the testis requires an interactive array of elements within its proximal promoter.Activity of the porcine gonadotropin-releasing hormone receptor gene promoter is partially conferred by a distal gonadotrope specific element (GSE) within an upstream enhancing region, two proximal GSEs and a retinoid X receptor binding site.Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and DifferentiationDAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita.Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineageMsx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope developmentGlucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotropeDivergent activity of the gonadotropin-releasing hormone receptor gene promoter among genetic lines of pigs is partially conferred by nuclear factor (NF)-B, specificity protein (SP)1-like and GATA-4 binding sites.Isolation of tumour stem-like cells from benign tumoursAdrenal hypoplasia congenita with hypogonadotropic hypogonadism: evidence that DAX-1 mutations lead to combined hypothalmic and pituitary defects in gonadotropin productionIdiopathic Hypogonadotropic Hypogonadism Caused by Inactivating Mutations in SRA1.Wide spectrum of NR5A1-related phenotypes in 46,XY and 46,XX individuals.Activation of the rat follicle-stimulating hormone receptor promoter by steroidogenic factor 1 is blocked by protein kinase a and requires upstream stimulatory factor binding to a proximal E box element.Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines.
P2860
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P2860
The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone alpha-subunit gene in pituitary gonadotropes.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The orphan nuclear receptor, s ...... ene in pituitary gonadotropes.
@en
type
label
The orphan nuclear receptor, s ...... ene in pituitary gonadotropes.
@en
prefLabel
The orphan nuclear receptor, s ...... ene in pituitary gonadotropes.
@en
P356
P1476
The orphan nuclear receptor, s ...... ene in pituitary gonadotropes.
@en
P2093
K M Barnhart
P L Mellon
P304
P356
10.1210/MEND.8.7.7527122
P577
1994-07-01T00:00:00Z