Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells.
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Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytesThe organization and consequences of eicosanoid signalingATP-binding cassette (ABC) transporters in normal and pathological lungMultidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical applicationMajor vault protein LRP-related multidrug resistanceMultidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD.Membrane localization and topology of leukotriene C4 synthase.The hydroxyl group of S685 in Walker A motif and the carboxyl group of D792 in Walker B motif of NBD1 play a crucial role for multidrug resistance protein folding and function.Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactorHydrogen-bond formation of the residue in H-loop of the nucleotide binding domain 2 with the ATP in this site and/or other residues of multidrug resistance protein MRP1 plays a crucial role during ATP-dependent solute transportInteraction between the bound Mg.ATP and the Walker A serine residue in NBD2 of multidrug resistance-associated protein MRP1 plays a crucial role for the ATP-dependent leukotriene C4 transportOverexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.Substrate recognition and transport by multidrug resistance protein 1 (ABCC1).Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretionTransmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Treatment heterogeneity in asthma: genetics of response to leukotriene modifiers.Eicosanoids in metabolic syndrome.Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport.ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter.Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure.Phase 0 and phase III transport in various organs: combined concept of phases in xenobiotic transport and metabolism.(R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1.Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1.ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transpoPhotolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione.Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells.GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter.Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport.Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein.Protein folding coupled to disulphide bond formation.Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice.Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione.ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918.Multidrug resistance protein. Identification of regions required for active transport of leukotriene C4.Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells.Replacement of the positively charged Walker A lysine residue with a hydrophobic leucine residue and conformational alterations caused by this mutation in MRP1 impair ATP binding and hydrolysisATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.Cells from chronic myelogenous leukaemia patients at presentation exhibit multidrug resistance not mediated by either MDR1 or MRP1.
P2860
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P2860
Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells.
@en
type
label
Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells.
@en
prefLabel
Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells.
@en
P2093
P2860
P1433
P1476
Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells.
@en
P2093
G Jedlitschky
U Buchholz
P2860
P304
P356
10.1111/J.1432-1033.1994.TB18661.X
P407
P577
1994-03-01T00:00:00Z