A mouse model of the most aggressive subgroup of human medulloblastoma - Wikidata - wikimedia - TriplyDB

A mouse model of the most aggressive subgroup of human medulloblastoma

A mouse model of the most aggressive subgroup of human medulloblastoma

http://www.wikidata.org/entity/Q41484437

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Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease Medulloblastoma stem cells: Promising targets in medulloblastoma therapy The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity In vivo Mn-enhanced MRI for early tumor detection and growth rate analysis in a mouse medulloblastoma model.Deriving therapies for children with primary CNS tumors using pharmacokinetic modeling and simulation of cerebral microdialysis data NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.The prenatal origins of cancer The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma MYC Deregulation in Primary Human Cancers.Mutation and expression analysis in medulloblastoma yields prognostic variants and a putative mechanism of disease for i17q tumors.Role of the miR-17∼92 cluster family in cerebellar and medulloblastoma development.Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity.Children's Oncology Group's 2013 blueprint for research: central nervous system tumors.Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.Orthotopic models of pediatric brain tumors in zebrafish Glial progenitors as targets for transformation in glioma.Deregulated proliferation and differentiation in brain tumors.Medulloblastoma subgroups remain stable across primary and metastatic compartments.Molecular subgroups of medulloblastoma.Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma.Molecular and in vivo characterization of cancer-propagating cells derived from MYCN-dependent medulloblastoma Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling Somatic cell transfer of c-Myc and Bcl-2 induces large-cell anaplastic medulloblastomas in mice.Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner.MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma.Genetic and molecular alterations across medulloblastoma subgroups

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A mouse model of the most aggressive subgroup of human medulloblastoma

http://www.wikidata.org/entity/Q41484437

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A mouse model of the most aggressive subgroup of human medulloblastoma

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A mouse model of the most aggressive subgroup of human medulloblastoma

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A mouse model of the most aggressive subgroup of human medulloblastoma

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A mouse model of the most aggressive subgroup of human medulloblastoma

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Chunxu Qu

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Cuilan Gao

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Daisuke Kawauchi

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David Finkelstein

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David W Ellison

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Jerold Rehg

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Paul Gibson

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Richard J Gilbertson

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Tamar Uziel

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P2860

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

Stem cells, cancer, and cancer stem cells

Identification of human brain tumour initiating cells

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Identification of stem cells in small intestine and colon by marker gene Lgr5

The Myc/Max/Mad network and the transcriptional control of cell behavior

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

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Martine F Roussel

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22340591

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medulloblastoma

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3285412

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